5-Iodo-2-thiophenecarbonitrile
- CAS No.
- 18945-81-8
- Chemical Name:
- 5-Iodo-2-thiophenecarbonitrile
- Synonyms
- 5-iodothiophene-2-carbonitrile;5-Iodo-2-thiophenecarbonitrile;2-Thiophenecarbonitrile, 5-iodo-
- CBNumber:
- CB32489998
- Molecular Formula:
- C5H2INS
- Molecular Weight:
- 235.05
- MDL Number:
- MFCD14584473
- MOL File:
- 18945-81-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Iodothiophene-2-carbonitrile | 9875AA | 250mg | $286 |
| 5-Iodothiophene-2-carbonitrile 95+% | 096853 | 250mg | $416 |
| 5-IODOTHIOPHENE-2-CARBONITRILE 95.00% | HCH0367504 | 5MG | $505.42 |
| 5-Iodothiophene-2-carbonitrile | 9875AA | 1g | $639 |
| 5-Iodothiophene-2-carbonitrile 95+% | 096853 | 1g | $924 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H312-H319-H335-H302-H332 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 |
5-Iodo-2-thiophenecarbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 9875AA | 5-Iodothiophene-2-carbonitrile | 18945-81-8 | 250mg | $286 | 2021-12-16 | Buy |
| Matrix Scientific | 096853 | 5-Iodothiophene-2-carbonitrile 95+% | 18945-81-8 | 250mg | $416 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0367504 | 5-IODOTHIOPHENE-2-CARBONITRILE 95.00% | 18945-81-8 | 5MG | $505.42 | 2021-12-16 | Buy |
| AK Scientific | 9875AA | 5-Iodothiophene-2-carbonitrile | 18945-81-8 | 1g | $639 | 2021-12-16 | Buy |
| Matrix Scientific | 096853 | 5-Iodothiophene-2-carbonitrile 95+% | 18945-81-8 | 1g | $924 | 2021-12-16 | Buy |
5-Iodo-2-thiophenecarbonitrile Chemical Properties,Uses,Production
Synthesis
1003-31-2
18945-81-8
Under nitrogen protection, 2-cyanothiophene (1 mmol) was dissolved in anhydrous THF (1.5 mL) in a flame-dried flask. TMPMgCl-LiCl (1.0 M solution of THF, 1.8 mL, 1.8 mmol) was slowly added dropwise at 25 °C and the reaction mixture was stirred for 2 h (for substrate 1a, it is recommended that the metallization time be kept within 1 h). The completion of the metallization reaction was monitored by GC analysis, and an aliquot of the reaction solution was taken and quenched with anhydrous THF solution of iodine (I2) to terminate the reaction. Subsequently, a solution of anhydrous THF (2 mL) with electrophilic reagent (2 mmol) was slowly added dropwise at 0 °C, and the temperature was raised to 25 °C to continue stirring for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous NaHCO3 solution. Extraction was carried out sequentially with NaHSO3 or NH4Cl solution (5 mL) and ethyl acetate (3 x 15 mL), the organic phases were combined and dried with anhydrous MgSO4. After filtration to remove the desiccant, the solvent was removed by distillation under reduced pressure to give the crude product 5-iodothiophene-2-carbonitrile.
References
[1] Synlett, 2015, vol. 26, # 20, p. 2795 - 2800
[2] Tetrahedron Letters, 1995, vol. 36, # 27, p. 4883 - 4884
5-Iodo-2-thiophenecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5-Iodo-2-thiophenecarbonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Changzhou Wanyao Biotechnology Co., Ltd. | 051989185693 15312551983 | 2410037592@qq.com | China | 1201 | 58 |
| China Langchem Inc. | 0086-21-58956006 | China | 7811 | 57 | |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| Modachem Shanghai Co., Ltd | +86 (0)21 51320687 51371369 1744605818 | China | 1578 | 58 | |
| Nanjing ERan Biological Pharmaceutical Co., Ltd. | 13770809694 | googlexu_0114@sina.com | China | 995 | 58 |
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