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Amantadine structure
Chemical Name:
C06818;Amanta;Pk-Merz;Symadine;Amantadin;Mantadine;NSC 341865;AMANTADINE;Amantidine;AMANTADINA
Molecular Formula:
Formula Weight:
MOL File:

Amantadine Properties

Melting point:
206-208 °C(lit.)
Boiling point:
263.29°C (rough estimate)
0.9510 (rough estimate)
refractive index 
1.5220 (estimate)
1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan
10.1(at 25℃)
White to cream
Water Solubility 
Soluble in organic solvents. Insoluble in water.
CAS DataBase Reference
768-94-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Tricyclo[, 7]decan-1-amine(768-94-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  YD1925000
HS Code  29213000
Hazardous Substances Data 768-94-5(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Amantadine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 138576 1-Adamantylamine 97% 768-94-5 5g $35.4 2018-11-13 Buy
Sigma-Aldrich 138576 1-Adamantylamine 97% 768-94-5 25g $169 2018-11-13 Buy
TCI Chemical A2318 1-Adamantanamine >98.0%(GC)(T) 768-94-5 5g $80 2018-11-22 Buy
TCI Chemical A2318 1-Adamantanamine >98.0%(GC)(T) 768-94-5 25g $253 2018-11-22 Buy
Alfa Aesar H30076 1-Adamantanamine, 98% 768-94-5 25g $131 2018-11-15 Buy

Amantadine Chemical Properties,Uses,Production


The anti-influenza A compound amantadine acts by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

Chemical Properties

White to cream powder


Building block for an L-piperidinamide catalyst used in an enantioselective Strecker reaction of phosphinoyl imines.1


ChEBI: A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.

brand name

Symadine (Solvay Pharmaceuticals); Symmetrel (Endo).

Antimicrobial activity

It inhibits influenza A virus replication at concentrations of 0.2– 0.6 mg/L, but has little or no activity against influenza B or C.

Acquired resistance

Resistance is the consequence of mutations in amino acid positions 27, 30 and 31 in the M2 transmembrane sequence. Cross-resistance between amantadine and rimantadine is universal. Influenza H3N2 strains worldwide are now resistant, but seasonal H1N1 strains remain susceptible. Postexposure family prophylaxis results in the prompt emergence of drug resistance after onset of treatment.

General Description

Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.

Pharmaceutical Applications

A symmetrical synthetic C-10 tricyclic amine with an unusual cage-like structure, supplied as the hydrochloride for oral administration.


Oral absorption: >90%
Cmax 200 mg oral per day: 0.4–0.9 mg/L after c. 4–6 h
Plasma half-life: 9.7–14.5 h
Volume of distribution: 10.4 L/kg
Plasma protein binding: 65%
Absorption and distribution
Absorption after oral administration is almost complete. Levels in secretions approach plasma concentrations.
Metabolism and excretion
About 56% of a single oral dose is excreted unchanged within 24 h by the kidney. Altogether 90% of an oral dose is excreted in the urine with a mean elimination half-life of 11.8 h in subjects with normal renal function. In elderly men, the half-life is 28.9 h and in patients with renal insufficiency half-lives of 18.5 h to 33.8 days have been observed. The renal clearance is around 398 mL/min (range 112–772 mL/min), indicating active secretion as well as glomerular filtration. Less than 5% of a dose is removed during hemodialysis and average half-lives of 8.3 and 13 days have been reported in patients on chronic hemodialysis. Extreme care must be taken to ensure that drug does not accumulate to toxic levels.

Clinical Use

Prevention and treatment of influenza A H1N1 infections

Side effects

Embryotoxicity and teratogenicity have been observed in rats receiving 50 mg/kg per day, about 15 times the usual human dose. Neurological side effects include drowsiness, insomnia, light-headedness, difficulty in concentration, nervousness, dizziness and headache in up to 20% of individuals. Other side effects include anorexia, nausea, vomiting, dry mouth, constipation and urinary retention. All develop during the first 3–4 days of therapy and are reversible by discontinuing the drug. An exception to rapid onset of adverse reactions is livedo reticularis. Convulsions, hallucinations and confusion are dose related, usually occurring at levels in excess of 1.5 mg/L; convulsions may occur at a lower threshold in patients with a history of epilepsy and the drug is best avoided in such patients.

Purification Methods

Dissolve the amine in Et2O, dry it over KOH, evaporate and sublime it in vacuo. [Stetter et al. Chem Ber 93 226 1960.]

Amantadine Preparation Products And Raw materials

Raw materials

Preparation Products

Amantadine Suppliers

Global( 236)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21954 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20095 58
(323) 306-3136
(626) 453-0409 United States 8409 58
career henan chemical co
+86-371-86658258 CHINA 20331 58
+86-830-2589033 China 99 69
86-22-88718329 China 42 58

View Lastest Price from Amantadine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-13 Amantadine
US $1.00 / KG 1KG 98% 1ton career henan chemical co

Amantadine Spectrum

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