ChemicalBook >> CAS DataBase List >>(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- CAS No.
- 1197953-49-3
- Chemical Name:
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- Synonyms
- (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
- CBNumber:
- CB32677388
- Molecular Formula:
- C12H12Cl2N3OP
- Molecular Weight:
- 316.12
- MDL Number:
- MFCD29477700
- MOL File:
- 1197953-49-3.mol
- MSDS File:
- SDS
Last updated:2024-04-09 22:15:29
| Boiling point | 527.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0.30±0.10(Predicted) |
| InChI | InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17) |
| InChIKey | XIKUAKVCJMVXCI-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 0956EB | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide | 1197953-49-3 | 250mg | $120 | 2021-12-16 | Buy |
| Chemenu | CM166384 | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 95% | 1197953-49-3 | 1g | $153 | 2021-12-16 | Buy |
| Ambeed | A117681 | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 96% | 1197953-49-3 | 5g | $335 | 2021-12-16 | Buy |
| Chemenu | CM166384 | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 95% | 1197953-49-3 | 5g | $421 | 2021-12-16 | Buy |
| Crysdot | CD11333969 | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 95+% | 1197953-49-3 | 5g | $446 | 2021-12-16 | Buy |
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemical Properties,Uses,Production
Uses
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.
Synthesis
25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.
Synthesis of (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide from 2-(diMethylphosphoryl)aniline and 2,4,5-Trichloropyrimidine
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Preparation Products And Raw materials
Global( 155)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | yusu@enkibiopharma.com | China | 47 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7933 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15933 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine pictures](/ProductImageEN/2023-11/Small/658d3a7f-c41a-425b-b4d7-cb89f0c2656c.jpg) |
2024-04-26 | 2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine
1197953-49-3
|
US $0.00 / kg | 10kg | 99.0% | 1000 | Enki Biopharmaceuticals (Shanghai) Limited | |
 |
2024-04-09 | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
1197953-49-3
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-01-09 | 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
1197953-49-3
|
US $0.00-0.00 / KG | 100g | 98% | KG | Suzhou Ryan Pharmachem Technology Co.,Ltd. |
-
- 2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine
1197953-49-3
- US $0.00 / kg
- 99.0%
- Enki Biopharmaceuticals (Shanghai) Limited
-
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
1197953-49-3
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
1197953-49-3
- US $0.00-0.00 / KG
- 98%
- Suzhou Ryan Pharmachem Technology Co.,Ltd.
1197953-49-3((2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide)Related Search:
1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro-
4-fluoro-2-Methoxy-5-nitroaniline
1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine
2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline
2-(diMethylphosphoryl)aniline
2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine
2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide
2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine
4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-
2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...
(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
AP26113 intermediates 1
1197953-49-3
197953-49-3
761140-75-9
C12H12Cl2N3OP
1197953-49-3