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Paprotrain

Paprotrain Structure
Paprotrain structure
CAS No.
57046-73-8
Chemical Name:
Paprotrain
Synonyms
Paprotrain;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
CBNumber:
CB32677878
Molecular Formula:
C16H11N3
Molecular Weight:
245.28
MDL Number:
MOL File:
57046-73-8.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:13
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Paprotrain Properties

Melting point 202℃
storage temp. 2-8°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form Powder

Paprotrain price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10524 Paprotrain ≥95% 57046-73-8 1mg $32 2024-03-01 Buy
Cayman Chemical 10524 Paprotrain ≥95% 57046-73-8 5mg $56 2024-03-01 Buy
Cayman Chemical 10524 Paprotrain ≥95% 57046-73-8 10mg $78 2024-03-01 Buy
Tocris 4813 Paprotrain ≥99%(HPLC) 57046-73-8 10 $81 2021-12-16 Buy
Tocris 4813 Paprotrain ≥99%(HPLC) 57046-73-8 50 $342 2021-12-16 Buy
Product number Packaging Price Buy
10524 1mg $32 Buy
10524 5mg $56 Buy
10524 10mg $78 Buy
4813 10 $81 Buy
4813 50 $342 Buy

Paprotrain Chemical Properties,Uses,Production

Description

Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.

Uses

Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2).

Paprotrain Preparation Products And Raw materials

Raw materials

Preparation Products

Paprotrain Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588 tauto@tautobiotech.com China 3989 66
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Jinan Kaixi Biotechnology Co., Ltd. 15853141736 461667177@qq.com China 511 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3445 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 7998 62
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4979 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Aladdin Scientific 		58
Shanghai Tauto Biotech Co., Ltd. 66
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Jinan Kaixi Biotechnology Co., Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
MQ (shanghai) Pharmaceuticals Co., Ltd. 55

57046-73-8(Paprotrain)Related Search:

METHYLENECYCLOHEXANE Nicotinamide
Paprotrain (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile 2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile 1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)- Kinesin,Paprotrain,Inhibitor,inhibit (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile 57046-73-8