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SHR1258

SHR1258 Structure
SHR1258 structure
CAS No.
1269662-73-8
Chemical Name:
SHR1258
Synonyms
SHR1258;HTI-1001;SHR-1258;Pyrotinib;SHR-1258;SHR1258;Pyrotinib (SHR-1258);Pyrotinib (free base);(R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide;2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)-
CBNumber:
CB33159982
Molecular Formula:
C32H31ClN6O3
Molecular Weight:
583.08
MDL Number:
MOL File:
1269662-73-8.mol
Last updated:2023-07-12 16:50:11
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SHR1258 Properties

Boiling point 775.5±60.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 0.172 mg/mL (0.29 mM)
pka 12.30±0.43(Predicted)
FDA UNII CJN36EQM0H
NCI Drug Dictionary pyrotinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280

SHR1258 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P997505 Pyrotinib 1269662-73-8 2.5mg $1365 2021-12-16 Buy
ChemScene CS-7940 Pyrotinib 99.61% 1269662-73-8 25mg $2340 2021-12-16 Buy
ChemScene CS-7940 Pyrotinib 99.61% 1269662-73-8 50mg $3540 2021-12-16 Buy
ChemScene CS-7940 Pyrotinib 99.61% 1269662-73-8 1mg $228 2021-12-16 Buy
ChemScene CS-7940 Pyrotinib 99.61% 1269662-73-8 5mg $780 2021-12-16 Buy
Product number Packaging Price Buy
P997505 2.5mg $1365 Buy
CS-7940 25mg $2340 Buy
CS-7940 50mg $3540 Buy
CS-7940 1mg $228 Buy
CS-7940 5mg $780 Buy

SHR1258 Chemical Properties,Uses,Production

Uses

Pyrotinib, is a potent and selective EGFR/HER2 dual inhibitor.

SHR1258 synthesis

1269662-79-4
852324-28-8
1269662-73-8
Synthesis of SHR1258 from Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester and (2R)-1-Methyl-2-Pyrrolidinecarboxaldehyde

SHR1258 Preparation Products And Raw materials

Raw materials

(2R)-1-Methyl-2-Pyrrolidinecarboxaldehyde Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile BOC-L-Prolinol L-(+)-Prolinol

Preparation Products

SHR1258 Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Beiwanta Biotechnology Co., Ltd. 021-67187366 19901745723 info@bwtlab.com China 9245 58
Supplier Advantage
Shanghai Beiwanta Biotechnology Co., Ltd. 58
SHR1258 SHR-1258 SHR-1258;SHR1258 Pyrotinib (SHR-1258) Pyrotinib 2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)- Pyrotinib (free base) HTI-1001 (R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide 1269662-73-8