ChemicalBook >> CAS DataBase List >>2-Bromopyridine


Chemical Name:
-Bromopyridine;-Bromoazine;2-Brompyridin;2-Bromopyridine;2-bromo-pyridin;o-Bromopyridine;2-pyridylbromide;AKOS BBS-00004324;BROMOPYRIDINE(2-);Pyridine,2-bromo-
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2022-11-11 11:01:00

2-Bromopyridine Properties

Melting point 193°C
Boiling point 192-194 °C (lit.)
Density 1.657 g/mL at 25 °C (lit.)
refractive index n20/D 1.572(lit.)
Flash point 130 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 20g/l
pka pK1: 0.71(+1) (25°C)
form Liquid
color Clear colorless to pale brown
Water Solubility Slightly miscible with water.
BRN 105789
Stability Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides.
LogP 1.42
CAS DataBase Reference 109-04-6(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 2-bromo-(109-04-6)
EPA Substance Registry System Pyridine, 2-bromo- (109-04-6)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Danger
Hazard statements  H301-H310-H315-H319-H335
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338
Hazard Codes  T,Xn,F
Risk Statements  10-24/25-36/37/38-23/24/25-20/21/22
Safety Statements  16-36/37-45-38-36/37/39-28A-26
RIDADR  UN 2929 6.1/PG 2
WGK Germany  3
RTECS  US3850000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  II
HS Code  29333999
NFPA 704
4 0

2-Bromopyridine price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B80100 2-Bromopyridine 99% 109-04-6 25g $38.2 2022-05-15 Buy
Sigma-Aldrich B80100 2-Bromopyridine 99% 109-04-6 100g $94.5 2022-05-15 Buy
TCI Chemical B0650 2-Bromopyridine >98.0%(GC) 109-04-6 25mL $48 2022-04-27 Buy
TCI Chemical B0650 2-Bromopyridine >98.0%(GC) 109-04-6 100mL $133 2022-04-27 Buy
Alfa Aesar A13241 2-Bromopyridine, 99% 109-04-6 100g $89.8 2021-12-16 Buy
Product number Packaging Price Buy
B80100 25g $38.2 Buy
B80100 100g $94.5 Buy
B0650 25mL $48 Buy
B0650 100mL $133 Buy
A13241 100g $89.8 Buy

2-Bromopyridine Chemical Properties,Uses,Production

Chemical Properties

light yellow oily or dark red liquid. miscible with ethanol, ether, benzene and pyridine, still soluble in water.


2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.


2-Bromopyridine can be used as:
A building block in the formation of C?N bond by various cross coupling reactions.
A reactant in Negishi cross-coupling reaction with aryl halides catalyzed by palladium.
A reactant in the synthesis of 2′-pyridyldifluoroacetate with ethyl bromodifluoroacetate in presence of copper as a catalyst.


2-Bromopyridine is synthesized from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (over 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise in a salt bath under freezing, and the rate of addition is to control the reaction temperature below -5°C appropriate. After adding, add sodium nitrite aqueous solution dropwise, control the reaction temperature to be below 0°C, stir for 20-30min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, and the 88°C-94°C/3333Pa fraction was collected to obtain the finished product of 2-bromopyridine with a yield of 83.8%.


2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, which is a versatile reagent.Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group.

Flammability and Explosibility


Purification Methods

Dry 2-bromopyridine over KOH for several days, then distil it from CaO under reduced pressure, and taking the middle fraction. [Beilstein 20/5 V 422.]

Global( 566)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Believe Chemical PTE.LTD
+8618906362908 China 1751 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106 China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29789 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21975 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 China 1807 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9377 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 CHINA 3012 60
career henan chemical co
+86-0371-86658258 China 29922 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338 China 2116 58

View Lastest Price from 2-Bromopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromopyridine pictures 2022-09-15 2-Bromopyridine
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Bromopyridine pictures 2022-03-04 2-Bromopyridine
US $10.00 / kg 1kg 99% 20tons Shandong Believe Chemical PTE.LTD
2-bromopyridine pictures 2022-02-22 2-bromopyridine
US $0.00 / KG 1KG 98.6% 100 tons Honest Joy Holdings Limited
  • 2-Bromopyridine pictures
  • 2-Bromopyridine
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
Pyridine,2-bromo- 2-BROMOPYRIDINE FOR SYNTHESIS 2-Bromopyridine≥ 99% (GC) TIMTEC-BB SBB003999 AKOS BBS-00004324 ALPHA-BROMOPYRIDINE BROMOPYRIDINE(2-) 2-BROMO PYRIDINE 2-BROMO PYRIDINE 2-Bromopyridine 2-broMide pyridine 2-BroMopyridine, 99% 100ML 2-BroMopyridine, 99% 25ML 2-bromo-pyridin 2-pyridylbromide beta-bromopyridine -Bromoazine o-Bromopyridine 2-Bromopyridine ,99% 2-BROMOPYRIDINE, 98%2-BROMOPYRIDINE, 98%2-BROMOPYRIDINE, 98%2-BROMOPYRIDINE, 98% 2-Brompyridin 2-Bromopyridine > 2-Bromopyridine, 99%, for synthesis 2-Bromopyridine,98% 2-Bromopyridine fandachem 2-Bromopyridine ISO 9001:2015 REACH -Bromopyridine 109-04-6 105-78-9 109-04-56 BrC5H4N C5H4NBr Halopyridines Bromopyridines Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Pyridines, Pyrimidines, Purines and Pteredines Halides Pyridines Pyridines derivates alkyl bromide C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Bromopyridines Halopyridines Pyridine bc0001