PF-6808472
- CAS No.
- 2088112-70-1
- Chemical Name:
- PF-6808472
- Synonyms
- XO44;PF-6808472;4-((4-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-6-(prop-2-yn-1-ylcarbamoyl)pyrimidin-2-yl)piperazin-1-yl)methyl)benzenesulfonyl fluoride;Benzenesulfonyl fluoride, 4-[[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-[(2-propyn-1-ylamino)carbonyl]-2-pyrimidinyl]-1-piperazinyl]methyl]-
- CBNumber:
- CB34668382
- Molecular Formula:
- C25H27FN8O3S
- Molecular Weight:
- 538.6
- MDL Number:
- MOL File:
- 2088112-70-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Symbol(GHS) | GHS05 |
| Signal word | Danger |
| Signal word | Danger |
| Hazard statements | H314 |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| RIDADR | UN 3265 8 / PGII |
PF-6808472 price More Price(2)
PF-6808472 Chemical Properties,Uses,Production
Uses
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].
Biochem/physiol Actions
PF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site.
IC 50
CDK4; CDK1; CDK2
References
[1] Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. DOI:10.1021/acs.jmedchem.1c00159
[2] Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366(6471):eaaw2106. DOI:10.1126/science.aaw2106
PF-6808472 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-6808472 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 1000 | 58 |
| Hangzhou Taorui Biotechnology Co., Ltd | 4000-360-990 15268198094 | sales@torreybio.com | China | 3549 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 26070 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13011 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
View Lastest Price from PF-6808472 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-28 | PF-6808472
2088112-70-1
|
US $455.00-787.00 / mg | 10g | TargetMol Chemicals Inc. |
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- PF-6808472
2088112-70-1
- US $455.00-787.00 / mg
- TargetMol Chemicals Inc.