Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal

CAS No.
Chemical Name:
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal
Synonyms
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal
CBNumber:
CB34669167
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal Properties

storage temp. -20°C
form buffered aqueous solution

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E2906 Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal clone C-273, purified from hybridoma cell culture 200μL $660 2024-03-01 Buy
Product number Packaging Price Buy
E2906 200μL $660 Buy

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal Chemical Properties,Uses,Production

Uses

Suitable for the following:

  • Immunohistochemistry
  • Indirect ELISA
  • Western blotting at a concentration of 0.25-0.5μg/mL using recombinant protein representing amino acids 299-359 of the Drosophila EGFR extracellular domain

General Description

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma C-273 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a recombinant protein encoding at the extracellular portion of Drosophila epidermal growth factor receptor (EGFR). Drosophila EGF receptor, also known as Torpedo or DER has four ligands: Gurken, Spitz (the principle ligand), Vein and Argos. Two accessory proteins modulate its signalling: Rhomboid and Star.

Biochem/physiol Actions

The epidermal growth factor receptor (EGFR) binds to its cognate ligands that lead to autophosphorylation of receptor tyrosine kinase and subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation and survival. EGFR is overexpressed in tumor cell lines and is associated with poor prognosis leading to decreased survival. Its activation also plays a role in resistance to chemotherapy and radiation treatment in tumor cells. EGFR tyrosine kinase inhibitors (TKIs) may act as a new treatment option for advanced lung adenocarcinoma. Its ligands function in the Drosophila CNS and maintains glial survival. Drosophila EGF receptor plays a critical role during the development of Drosophila retina.

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal