POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE
- CAS No.
- Chemical Name:
- POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE
- Synonyms
- POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE
- CBNumber:
- CB34744569
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE price More Price(2)
POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
POMALIDOMIDE-PEG1-NH2 HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |