Autotaxin Inhibitor II, HA130 - Calbiochem
- CAS No.
- Chemical Name:
- Autotaxin Inhibitor II, HA130 - Calbiochem
- Synonyms
- Autotaxin Inhibitor II, HA130 - Calbiochem
- CBNumber:
- CB34816891
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Autotaxin Inhibitor II, HA130 - Calbiochem price More Price(1)
Autotaxin Inhibitor II, HA130 - Calbiochem Chemical Properties,Uses,Production
General Description
A thiazolidinedione that is designed to target the ATX active site thr210 with a boronic moiety and shown to potently inhibit ATX lysoPLD activity (IC50 ~28 nM using recombinant human ATX or human plasma) in a reversible manner with a mixed-type Lineweaver-Burk kinetics. Reported to exhibit low cytotoxicity (TD50 = 83, 105, and 2056 μM in HEK293T, A2058, and HepG2 cultures) and no activity toward NPP1, PDE, AP, or proteasomal chymotryptic/tryptic/caspase-like activities even at concentrations as high as 10 μM. Although HA130 quickly and effectively reduces circulating LPA level when injected in mice (463 μg/kg, i.v.) in vivo, the effect appears short-lived as is the case with S32826 (Cat. No.189510).
Autotaxin Inhibitor II, HA130 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Autotaxin Inhibitor II, HA130 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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Sigma-Aldrich | 80 |
Autotaxin Inhibitor II, HA130 - Calbiochem