Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem

CAS No.
Chemical Name:
Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem
Synonyms
Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem
CBNumber:
CB34817616
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 475857 Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem 10mg $264 2023-01-07 Buy
Product number Packaging Price Buy
475857 10mg $264 Buy

Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable dihydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22 nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10 μM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin (Cat. No. 232120), possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1 μM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities.

Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem Suppliers

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Mirk/Dyrk1B Inhibitor, Compound A - Calbiochem