ChemicalBook >> CAS DataBase List >>Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-

Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-

Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- structure

CAS No.: 1973408-76-2

Chemical Name:: Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-

Synonyms: ABM-14;4-[3-[4-(4-hydroxyphenyl)phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile;Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-;Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-

CBNumber:: CB38188262

Molecular Formula:: C25H18F3N3O2S

Molecular Weight:: 481.49

MDL Number:

MOL File:: 1973408-76-2.mol

Last updated:2023-02-23 14:24:08

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Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Properties

Boiling point	620.0±65.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
pka	9.60±0.26(Predicted)

Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Chemical Properties,Uses,Production

Biological Activity

ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR[1].

References

[1]. Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1.

Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1362	58
Hebei Yaocheng Pharmaceutical Technology Co. Ltd	0311-88802076 13171568381	info@yaochengph.com	China	2115	58
csynbio	15051477682	changming.pan@csynbio.com	China	225	58

Supplier	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	58
Hebei Yaocheng Pharmaceutical Technology Co. Ltd	58
csynbio	58

ABM-14 Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- 4-[3-[4-(4-hydroxyphenyl)phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- 1973408-76-2 C25H18F3N3O2S