ChemicalBook >> CAS DataBase List >>4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)-

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)-

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- structure

CAS No.: 2270984-21-7

Chemical Name:: 4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)-

Synonyms: Gcase activator 3;(S)-N-[(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl]-N-methyl-2-(3-pyridyl)quinazolin-4-amine;4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)-

CBNumber:: CB38848137

Molecular Formula:: C23H20N4O2

Molecular Weight:: 384.43

MDL Number:

MOL File:: 2270984-21-7.mol

Last updated:2025-10-29 15:43:00

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4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Properties

Boiling point	492.8±45.0 °C(Predicted)
Density	1.277±0.06 g/cm3(Predicted)
pka	4.74±0.30(Predicted)

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Chemical Properties,Uses,Production

Uses

Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1].

References

[1] Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230. DOI:10.1021/acs.jmedchem.8b01294

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	955	58
Shaoyuan Technology (Shanghai) Co., Ltd.	021-50795510 4000665055	sy-c6@accelachem.com	China	10000	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29641	58

Supplier	Advantage
Suzhou Chenrui Biotechnology Co. LTD	58
Shaoyuan Technology (Shanghai) Co., Ltd.	58
TargetMol Chemicals Inc.	58

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Spectrum

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)-(2270984-21-7)¹HNMR

4-Quinazolinamine, N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-N-methyl-2-(3-pyridinyl)- Gcase activator 3 (S)-N-[(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl]-N-methyl-2-(3-pyridyl)quinazolin-4-amine 2270984-21-7