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ChemicalBook >> CAS DataBase List >>2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)-

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)-

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- Structure
2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- structure
CAS No.
2247061-09-0
Chemical Name:
2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)-
Synonyms
DI-1859;2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)-
CBNumber:
CB410673762
Molecular Formula:
C30H45N5O3S
Molecular Weight:
555.78
MDL Number:
MOL File:
2247061-09-0.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- Properties

Boiling point 806.1±65.0 °C(Predicted)
Density 1.138±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 13.79±0.46(Predicted)

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- Chemical Properties,Uses,Production

Biological Activity

DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage[1].

References

[1]. Zhou H, et al. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nat Commun. 2021;12(1):2621.

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5019 58
Supplier Advantage
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[2-[(dimethylamino)methyl]-1-oxo-2-propen-1-yl]amino]ethyl]-6-(1-methylethyl)-α-[(1-oxopropyl)amino]-, (αS)- DI-1859 2247061-09-0