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20(R)-Ginsenoside Rg3

20(R)-Ginsenoside Rg3
20(R)-Ginsenoside Rg3 structure
CAS No.
38243-03-7
Chemical Name:
20(R)-Ginsenoside Rg3
Synonyms
CID 9918693;Ginsenoside Rg;Ginseonoside Rg3;20(r)-propanaxadiol;Ginsenoside Rg3 Rh2;Ginsenoside Rg3 (R-);20(R)-Ginsenoside Rg3;R-form-Ginsenoside Rg3;20(SR)-Ginsenoside Rg3;Ginsenoside Rg3 (R-Form)
CBNumber:
CB42130576
Molecular Formula:
C42H72O13
Formula Weight:
785.01
MOL File:
38243-03-7.mol

20(R)-Ginsenoside Rg3 Properties

Melting point:
315-318 ºC
Boiling point:
885.0±65.0 °C(Predicted)
Density 
1.30
pka
12.85±0.70(Predicted)

20(R)-Ginsenoside Rg3 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24978 20(R)-Ginsenoside Rg3 ≥95% 38243-03-7 50mg $119 2021-03-22 Buy
Cayman Chemical 24978 20(R)-Ginsenoside Rg3 ≥95% 38243-03-7 100mg $190 2021-03-22 Buy
Cayman Chemical 24978 20(R)-Ginsenoside Rg3 ≥95% 38243-03-7 250mg $446 2021-03-22 Buy

20(R)-Ginsenoside Rg3 Chemical Properties,Uses,Production

Description

Ginsenoside Rg3 is mainly derived from the dried roots of Araliaceae Panax ginseng C.A.?Mey. and Panax quinquefolius L.?Ginseng has a long history of medicinal uses, well known as “king of herbs.” Ginseng is listed as the top grade in “Shen Nong’s herbal class,” with “the main security set up the five internal organs, spirit, soul, stop fright, in addition to evil, eyesight, fun puzzle” account. The traditional Chinese medicine regards ginseng as the top grade of reinforcing Qi, with Dabu strength, spleen and lungs, Sheng Jin, Anshen Yizhi, etc.

Physical properties

Appearance: white powder. Density: 1.40. Melting point: 315–318?°C. Solubility: 20(R)-ginsenoside Rg3 is soluble in methanol and ethanol; low water solubility; insoluble in ether and chloroform. Storage temperature: 2–8?°C.?The component classification belongs to three dammarane tetracyclic triterpenoid saponins.

History

Ginseng is currently one of the most studied traditional medicines. Chemical researches certificate that ginseng contains a variety of ginseng saponin, ginseng polysaccharide, protein, polypeptide, amino acids, and other chemical constituents. Ginseng saponins are the main active components, accounting for about 4%. Ginsenoside is a kind of sterol compound, which has a similar basic structure. Ginsenoside contains the steroid nucleus of 17 carbon atoms arranged in 4 rings. At present, more than 40 kinds of ginsenosides have been isolated from ginseng. They are divided into four types according to their chemical structure, the protopanaxadiol, the protopanaxatriol, the ocotillol, and the oleanolic acid.
Ginsenoside Rg3 is a dammarane tetracyclic triterpenoid saponin found in natural ginseng, which belongs to the protopanaxadiol . It is also the natural ingredient with prominent activity extracted from red ginseng (processed ginseng). Modern medicine has proved that Rg3 has certain biological activity. Since 1983, Rg3 has been widely studied by many scholars in the world . The results showed that the content of ginsenoside Rg3 in the fresh and dried ginseng roots was less than 1 ppm while in red ginseng was 3/100,000. After several years of research, the method of extracting 20(R)-ginsenoside Rg3 from red ginseng has been successfully improved, and the industrialized production has been realized. A multicenter clinical study by eight domestic hospitals indicated that 20(R)-ginsenoside Rg3 has therapeutic effects on tumor. It has been issued the new drug certificate by the Chinese Food and Drug Administration, as a new anticancer drug approved.

Indications

This product is contained in “New drug standards” the 87th volume.
Ginsenoside Rg3 capsule, ginsenoside Rg3 emulsion, and ginsenoside Rg3 microemulsion are mainly used in the clinical treatment or adjuvant therapy of lung cancer, breast cancer, liver cancer, gastric cancer, colon cancer, etc. In addition, they improve and prevent the common diseases in the elderly such as cardiovascular disease, coronary heart disease, limb weakness, difficulty walking, and loss of memory. Ginsenoside Rg3 also has a certain biological activity in antiviral, radiosensitization, and treatment of chronic obstructive pulmonary disease.

Pharmacology

It is reported that the antitumor effects of ginsenoside Rg3 and Rh2 were the most significant in more than 40 kinds of ginsenosides obtained. Moreover, they enhanced the immune function of tumor patients after chemotherapy, including humoral immunity, cell immunity, and non-specific immunity . This effect is consistent with the vitality nourishing and body strengthening of ginseng in the theory of traditional Chinese medicine. There is more research on the effects of 20(R)-ginsenoside Rg3?in the two isomers of ginsenoside Rg3, which has certain inhibitory effects on tumor cells of lung cancer, gastric cancer, colon cancer, breast cancer, liver cancer, etc. There is less research on the effects of 20(S)-ginsenoside Rg3. Other studies have shown that ginsenoside Rg3 also has the effects of anti-fatigue , antiviral , and treatment of chronic obstructive pulmonary disease .
Human tolerance test shows that ginsenoside Rg3 has a wide safety range. The recommended dose of the first phase of clinical trial (0.8 mg/kg/day) has no side effects. Ginsenoside Rg3 has good oral absorption. The drug absorption peak in the blood is detected after administration for 15–30 min, and the blood concentration reaches the peak after administration for 1.0–1.5 h. The half-life is 4.84±1.41 h. The maximum blood concentration increases with the dose within the reagent range (0.8–3.2 mg/kd/day), suggesting the pharmacokinetics of ginsenoside Rg3 the firstorder kinetics process.

Clinical Use

The basic research for many years and a large number of clinical data confirm that ginsenoside Rg3 effectively inhibits the growth of lung cancer, liver cancer, gastric cancer, colon cancer, and breast cancer, significantly improves the clinical symptoms of patients, improves the quality of life, and prevents and treats cancer. Ginsenoside Rg3 effectively improves the ability of anti-fatigue, antiaging, and resistance to disease. It also improves cardiovascular function, is resistant to platelet aggregation, protects nerve cells of brain, and improves immunity.
Ginsenoside Rg3 is the active ingredient of Shenyi (参一) capsule which is a kind of traditional Chinese anticancer medicine developed in China. It prevents the metastasis and recurrence of cancer and has been an adjuvant treatment in multiple tumors . Shenyi capsule improves the curative effects of primary lung cancer and liver cancer, relieves the symptoms of Qi deficiency, as well as improves immunity, when combined with chemotherapy. Further study on the antitumor mechanism of ginsenoside Rg3 will be helpful to the clinical application of this drug.

20(R)-Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products


20(R)-Ginsenoside Rg3 Suppliers

Global( 126)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 376 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2471 58

View Lastest Price from 20(R)-Ginsenoside Rg3 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-17 20(R)Ginsenoside Rg3
38243-03-7
US $0.00-0.00 / KG 1g/Bag 8%,16%,39%,90%,98% 2000KG NanJing Spring & Autumn Biological Engineering CO., LTD.
2020-05-11 20(R)-Ginsenoside Rg3
38243-03-7
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2020-01-09 20(R)-Ginsenoside Rg3
38243-03-7
US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

38243-03-7(20(R)-Ginsenoside Rg3)Related Search:


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