Edoxaban hydrochloride
- CAS No.
- 480448-29-1
- Chemical Name:
- Edoxaban hydrochloride
- Synonyms
- Edoxaban Hcl;Edoxaban (HCl salt);Edoxaban hydrochloride;Edoxaban Monohydrochloride;N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide:hydrochloride;N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide hydrochloride
- CBNumber:
- CB42549583
- Molecular Formula:
- C24H31Cl2N7O4S
- Molecular Weight:
- 584.51844
- MDL Number:
- MOL File:
- 480448-29-1.mol
- MSDS File:
- SDS
| FDA UNII | 606P02282F |
|---|
Edoxaban hydrochloride Chemical Properties,Uses,Production
Description
Edoxaban (Lixiana), a direct inhibitor of Factor Xa (FXa) was approved by the Minister of Health, Labor, and Welfare in Japan in April 2011 for the prevention of venous thromboembolism (VTE) after major orthopedic surgery. Edoxaban inhibits hFXa with a Ki=0.56 nM. Edoxaban is a weak inhibitor of thrombin Ki=6000 nM, has >10,000 fold selectivity over other serine proteases in the coagulation cascade, and demonstrates selectivity over trypsin and chymotrypsin. The synthesis of this class of FXa inhibitors begins with assembly of the diaminocyclohexane scaffold, cis-t-butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate. The free amine is coupled to the P1 group, 2-((5-chloropyridin-2-yl) amino)-2-oxoacetic acid. The Boc protecting group on the amine of the scaffold is removed and the resulting free amine is coupled to the P4 group, 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid.
Originator
Daiichi Pharmaceutical (Japan)
brand name
Lixiana
Edoxaban hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Edoxaban hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28820 | 58 |
| Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 | CHINA | 4880 | 58 | |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| SPIRO PHARMA | 55 |
| Amatek Scientific Co. Ltd. | 58 |
| Nanjing crow LuNing pharmaceutical technology co., LTD | 58 |
| TargetMol Chemicals Inc. | 58 |