MGL-3196
- CAS No.
- 920509-32-6
- Chemical Name:
- MGL-3196
- Synonyms
- Resmetirom;VIA3196;CS-2429;VIA-3196;MGL-3196;MGL-3196(Resmetirom);Resmetirom(MGL-3196);Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
- CBNumber:
- CB42714673
- Molecular Formula:
- C17H12Cl2N6O4
- Molecular Weight:
- 435.22
- MDL Number:
- MFCD26142653
- MOL File:
- 920509-32-6.mol
- MSDS File:
- SDS
| Density | 1.65±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.96±0.40(Predicted) |
| FDA UNII | RE0V0T1ES0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MGL-3196 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23845 | MGL-3196 ≥98% | 920509-32-6 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 23845 | MGL-3196 ≥98% | 920509-32-6 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 23845 | MGL-3196 ≥98% | 920509-32-6 | 10mg | $341 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0018402 | MGL-3196 95.00% | 920509-32-6 | 5MG | $505.57 | 2021-12-16 | Buy |
| DC Chemicals | DC9995 | MGL-3196(Resmetirom) >98% | 920509-32-6 | 100mg | $600 | 2021-12-16 | Buy |
MGL-3196 Chemical Properties,Uses,Production
Description
MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.
MGL-3196 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |