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2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Structure
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid structure
CAS No.
32675-71-1
Chemical Name:
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
Synonyms
(Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
CBNumber:
CB43372267
Molecular Formula:
C19H14N2O4
Molecular Weight:
334.33
MDL Number:
MOL File:
32675-71-1.mol
Last updated:2023-07-02 08:28:07
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2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Properties

Boiling point 606.0±50.0 °C(Predicted)
Density 1.502±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Yellow solid
pka 3.62±0.10(Predicted)

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 260920 DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem 32675-71-1 10mg $245 2024-03-01 Buy
Product number Packaging Price Buy
260920 10mg $245 Buy

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemical Properties,Uses,Production

General Description

A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Biochem/physiol Actions

Cell permeable: yes

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid synthesis

85-44-9
54-12-6
32675-71-1
Synthesis of 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid from Phthalic anhydride and DL-Tryptophan

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemStrong Scientific Co.,Ltd 0755-66853366 13670046396 sales@chem-strong.com China 17982 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Zhengzhou Ruike Biochemical Technology Co., Ltd. 18521304688 421551521@qq.com China 201 58
Changzhou Xianglong Pharmaceutical Technology Co., LTD 18661161657 yaoxiangqiu2021@163.com China 10066 58
Yantai Sheng Kai Lun Biological Products Co. , Ltd. 3119594100 mark@sklnchem.cn China 7107 58
Shanghai Haohong Scientific Co., Ltd. 400-400-8210725 malulu@leyan.com China 40041 58
Tan-Mo Technology Co., Ltd. 19850211281 qiann@gbw-china.com China 1980 58
Nantong Hanfang Biotechnology Co. , Ltd. 3674309880 hanfangpharma@126.com China 30968 58
Supplier Advantage
ChemStrong Scientific Co.,Ltd 56
Sigma-Aldrich 80
Zhengzhou Ruike Biochemical Technology Co., Ltd. 58
Changzhou Xianglong Pharmaceutical Technology Co., LTD 58
Yantai Sheng Kai Lun Biological Products Co. , Ltd. 58
Shanghai Haohong Scientific Co., Ltd. 58
Tan-Mo Technology Co., Ltd. 58
Nantong Hanfang Biotechnology Co. , Ltd. 58
2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem 1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)- (Rac)-RG108 32675-71-1