Anti-Factor IX antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Factor IX antibody, Mouse monoclonal
- Synonyms
- Anti-Factor IX antibody, Mouse monoclonal
- CBNumber:
- CB44669205
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Factor IX antibody, Mouse monoclonal price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F2645 | Anti-Factor IX antibody, Mouse monoclonal clone HIX-1, purified from hybridma cell culture | 0.2mL | $514 | 2024-03-01 | Buy | |
Sigma-Aldrich | F1020 | Anti-Factor IX antibody, Mouse monoclonal clone HIX-5, purified from hybridoma cell culture | 0.2ML | $528 | 2024-03-01 | Buy |
Anti-Factor IX antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)
General Description
Anti Factor IX antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the HIX-1 hybridoma produced by the fusion of mouse Sp2/0-Ag14 myeloma cells and splenocytes from BALB/c mice immunized with factor IX purified from human plasma. Factor IX concentration in human plasma ranges between 2.5-5 mg/ml and its half-life is approximately 24 hours. The human factor IX gene is about 40 Kb in size and is localized at the distal end of the X-chromosome.
Biochem/physiol Actions
FIX plays a key role in the intrinsic and extrinsic blood coagulation systems. It is synthesized in liver and later upon activation in plasma it gets converted into a serine protease. In second step, FIX undergoes series of complex post-translation modifications such as γ-carboxylation of 12 N-terminal glutamic acid residues, N- and O-linked glycosylation, phosphorylation, β-hydroxylation, sulfation, disulfide bond formation etc. It is secreted into the plasma after completion of post-translation modifications. Hereditary deficiencies or dysfunctions of factor IX cause hemophilia B or "Christmas Disease" (the surname of the first family described). In haemophilia B, FIX showed impaired coagulation and increased tendency to bleed as a reason of mutation in the X chromosome linked FIX gene. Factor IX is synthesized in liver parenchymal cells and requires a post-translational vitamin K-dependent modification in order to become a mature plasma zymogen. When patients lack vitamin-K or take oral anticoagulants that interfere with the metabolism of vitamin-K, a hypocoagulable or antithrombotic state is induced.
Anti-Factor IX antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Factor IX antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |