ZP1846
- CAS No.
- 914009-84-0
- Chemical Name:
- ZP1846
- Synonyms
- ZP1846;Elsiglutide
- CBNumber:
- CB44713858
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| Sequence | His-Gly-Glu-Gly-Ser-Phe-Ser-Ser-Glu-Leu-Ser-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2 |
|---|---|
| FDA UNII | SC864Q40VB |
| NCI Drug Dictionary | elsiglutide |
ZP1846 Chemical Properties,Uses,Production
Uses
Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib.html" class="link-product" target="_blank">Lapatinib (HY-50898)-induced diarrhoea in rat model[1][2].
in vivo
Elsiglutide (500 mg/kg; p.o.; once daily; 4 times per week for 4 weeks) reduces the most severe diarrhoea seen from Lapatinib (500 mg/kg; p.o.) in rat model[1].
| Animal Model: | Male Albino Wistar rats (250-280 g)[1] |
| Dosage: | 500 mg/kg, with or not 500 mg/kg Lapatinib |
| Administration: | Oral gavage; once daily, 4 non-consecutive days per week with vehicle solution being administered on the other 3 days for 4 weeks |
| Result: | Resulted less?incidence of?diarrhoea compared to?lapatinib alone. Signifcantly less weight gain from day 7 of treatment compared to control. |
References
[1] Mayo BJ, et al. The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats. Cancer Chemother Pharmacol. 2020 Apr;85(4):793-803. DOI:10.1007/s00280-020-04040-0
[2] Mayo B, et al. The new selective glp-2 receptor agonist, elsiglutide, improves irinotecan-induced diarrhoea and mucositis in the rat. Asia Pacific Journal of Clinical Oncology, 2014, vol.10, iss.Suppl. 8, pp.134-134.
ZP1846 Preparation Products And Raw materials
Raw materials
Preparation Products
ZP1846 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| Hubei KDG Web Science&Technology Co., Ltd | 18672314556 +8618672314556 | sales@kdg-tech.com | China | 933 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 16077 | 64 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7408 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3061 | 58 |
| Hangzhou Xinhai Pharmaceutical Technology Co., Ltd. | 0571-86758863 13867485072 | lulu@thinheal.com | China | 262 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2395 | 58 |
| Wuhan Dingxintong Pharmaceutical Co. , Ltd. | 15871722230 | 15871722230@163.com | China | 4686 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-0571-88211921 19105816207 | sales4@gotopbio.com | China | 5144 | 58 |
