Caspase Inhibitor Set III - Calbiochem
- CAS No.
- Chemical Name:
- Caspase Inhibitor Set III - Calbiochem
- Synonyms
- Caspase Inhibitor Set III - Calbiochem
- CBNumber:
- CB44816959
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Caspase Inhibitor Set III - Calbiochem price More Price(1)
Caspase Inhibitor Set III - Calbiochem Chemical Properties,Uses,Production
General Description
Apoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.
Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
Biochem/physiol Actions
Cell permeable: yes
Caspase Inhibitor Set III - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Caspase Inhibitor Set III - Calbiochem Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |