ANTI-NICASTRIN
- CAS No.
- Chemical Name:
- ANTI-NICASTRIN
- Synonyms
- Anti-APH-2;Anti-MGC2993;ANTI-NICASTRIN;Anti-Anterior pharynx defective 2;Anti-ZDHHC16 antibody produced in rabbit;Anti-Zinc finger, DHHC-type containing 16;Anti-Nicastrin antibody produced in rabbit;Anti-Nicastrin (ab2) antibody produced in rabbit;Anti-Nicastrin (ab1) antibody produced in rabbit
- CBNumber:
- CB4487092
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03791914
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 21/22-52/53 |
| Safety Statements | 36/37-61 |
| WGK Germany | - |
ANTI-NICASTRIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PRS3985 | Anti-Nicastrin (ab2) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 100μG | $503 | 2023-06-20 | Buy | |
| Sigma-Aldrich | N1660 | Anti-Nicastrin antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 0.2ML | $558 | 2023-06-20 | Buy | |
| Sigma-Aldrich | AV50062 | Anti-ZDHHC16 antibody produced in rabbit affinity isolated antibody | 100μL | $503 | 2023-01-07 | Buy |
ANTI-NICASTRIN Chemical Properties,Uses,Production
Uses
Anti-Nicastrin antibody produced in rabbit has been used in:
- western blotting
- immunoprecipitation
- co-immunoprecipitation
General Description
Nicastrin (NCSTN) is a type I transmembrane glycoprotein (709 amino acids) that interacts with both presenilin-1 (PS1) and presenilin-2 (PS2). This gene is located on human chromosome 1q23.
Biochem/physiol Actions
Nicastrin has a key role in the regulation of presenilin-mediated cleavage of the b-amyloid precursor protein (b-APP) and Notch/GLP-1. Nicastrin binds to the membrane-tethered form of Notch and is essential for the intramembrane cleavage of Notch to generate Notch intracellular domain (NICD), which is involved in intracellular signaling. It has been suggested that nicastrin binds substrates of presenilin/g-secretase complexes or modulates g-secretase activity. Suppression of nicastrin expression in C. elegansembryos induces a subset of notch/glp-1 phenotypes similar to those induced by simultaneous null mutations in both presenilin homologues of C. elegans (sel-12 and hop-1). Thus, increasing evidence indicates that both nicastrin and presenilins are necessary components for the intramembrane proteolysis of proteins such as b-APP and Notch, and implicates a direct role for nicastrin in the pathogenesis of Alzheimer′s disease and in the regulation of Notch signaling in vivo.
ANTI-NICASTRIN Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-NICASTRIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |