ANTI-NICASTRIN

CAS No.
Chemical Name:
ANTI-NICASTRIN
Synonyms
Anti-APH-2;Anti-MGC2993;ANTI-NICASTRIN;Anti-Anterior pharynx defective 2;Anti-ZDHHC16 antibody produced in rabbit;Anti-Zinc finger, DHHC-type containing 16;Anti-Nicastrin antibody produced in rabbit;Anti-Nicastrin (ab2) antibody produced in rabbit;Anti-Nicastrin (ab1) antibody produced in rabbit
CBNumber:
CB4487092
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD03791914
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

ANTI-NICASTRIN Properties

storage temp. −20°C
form buffered aqueous solution

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  21/22-52/53
Safety Statements  36/37-61
WGK Germany  -

ANTI-NICASTRIN price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PRS3985 Anti-Nicastrin (ab2) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 100μG $503 2023-06-20 Buy
Sigma-Aldrich N1660 Anti-Nicastrin antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 0.2ML $558 2023-06-20 Buy
Sigma-Aldrich AV50062 Anti-ZDHHC16 antibody produced in rabbit affinity isolated antibody 100μL $503 2023-01-07 Buy
Product number Packaging Price Buy
PRS3985 100μG $503 Buy
N1660 0.2ML $558 Buy
AV50062 100μL $503 Buy

ANTI-NICASTRIN Chemical Properties,Uses,Production

Uses

Anti-Nicastrin antibody produced in rabbit has been used in:

  • western blotting
  • immunoprecipitation
  • co-immunoprecipitation

General Description

Nicastrin (NCSTN) is a type I transmembrane glycoprotein (709 amino acids) that interacts with both presenilin-1 (PS1) and presenilin-2 (PS2). This gene is located on human chromosome 1q23.

Biochem/physiol Actions

Nicastrin has a key role in the regulation of presenilin-mediated cleavage of the b-amyloid precursor protein (b-APP) and Notch/GLP-1. Nicastrin binds to the membrane-tethered form of Notch and is essential for the intramembrane cleavage of Notch to generate Notch intracellular domain (NICD), which is involved in intracellular signaling. It has been suggested that nicastrin binds substrates of presenilin/g-secretase complexes or modulates g-secretase activity. Suppression of nicastrin expression in C. elegansembryos induces a subset of notch/glp-1 phenotypes similar to those induced by simultaneous null mutations in both presenilin homologues of C. elegans (sel-12 and hop-1). Thus, increasing evidence indicates that both nicastrin and presenilins are necessary components for the intramembrane proteolysis of proteins such as b-APP and Notch, and implicates a direct role for nicastrin in the pathogenesis of Alzheimer′s disease and in the regulation of Notch signaling in vivo.

ANTI-NICASTRIN Preparation Products And Raw materials

Raw materials

Preparation Products

ANTI-NICASTRIN Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
ANTI-NICASTRIN Anti-Nicastrin antibody produced in rabbit Anti-Nicastrin (ab1) antibody produced in rabbit Anti-MGC2993 Anti-ZDHHC16 antibody produced in rabbit Anti-Zinc finger, DHHC-type containing 16 Anti-Anterior pharynx defective 2 Anti-APH-2 Anti-Nicastrin (ab2) antibody produced in rabbit Alphabetical Index Antibodies for Alzheimer and Neurodegenerative Disease ResearchAntibodies Antibodies for Neurobiology Antibodies for Neurodegenerative Diseases Research N