β3-AR agonist 1
- CAS No.
- 1283125-73-4
- Chemical Name:
- β3-AR agonist 1
- Synonyms
- β3-AR agonist 1;β3-AR agonist 1;β3 AR agonist 1,β3AR agonist 1;Cyclobutanesulfonamide, N-[3-[(1R)-1-hydroxy-2-[[2-[(3-methyl-1H-indazol-6-yl)oxy]ethyl]amino]ethyl]phenyl]-
- CBNumber:
- CB45763070
- Molecular Formula:
- C22H28N4O4S
- Molecular Weight:
- 444.55
- MDL Number:
- MFCD32174249
- MOL File:
- 1283125-73-4.mol
β3-AR agonist 1 Chemical Properties,Uses,Production
Description
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1]. EC50: 18 nM (β3-AR)[1]
β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].
References
[1]. Wada Y, et al. Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. J Med Chem. 2017 Apr 27;60(8):3252-3265.
β3-AR agonist 1 Preparation Products And Raw materials
Raw materials
Preparation Products
β3-AR agonist 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |