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Tubulysin I

Tubulysin I structure

CAS No.: 799822-10-9

Chemical Name:: Tubulysin I

Synonyms: Tubulysin I;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-

CBNumber:: CB45821200

Molecular Formula:: C40H59N5O10S

Molecular Weight:: 801.99

MDL Number:: MFCD32197436

MOL File:: 799822-10-9.mol

Last updated:2025-04-18 09:52:20

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Tubulysin I Properties

Boiling point	967.4±65.0 °C(Predicted)
Density	1.222±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	4.52±0.23(Predicted)

Tubulysin I Chemical Properties,Uses,Production

Uses

Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

References

[1] Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. DOI:10.1002/anie.200906828
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041

Tubulysin I Preparation Products And Raw materials

Raw materials

Preparation Products

Tubulysin I Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32334	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12306	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9729	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 18679456698	mingxinzhu@huidabiotech.com	China	3441	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29770	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9835	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
Zhejiang Huida Biotech Co., LTD	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
RD International Technology Co., Limited	58

Tubulysin I Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)- 799822-10-9 C40H59N5O10S