ANTI-CONNEXIN 43

CAS No.
Chemical Name:
ANTI-CONNEXIN 43
Synonyms
Anti-ODDD;Anti-GJAL;ANTI-CX43;Anti-DFNB38;ANTI-CONNEXIN 43;Anti-GJA1 antibody produced in goat;gap junction protein, alpha 1, 43kDa;Anti-CX43 antibody produced in rabbit;Anti-GJAL antibody produced in rabbit;Anti-ODDD antibody produced in rabbit
CBNumber:
CB4680521
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00803532
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

ANTI-CONNEXIN 43 Properties

storage temp. -20°C
form buffered aqueous solution

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  21/22
Safety Statements  36/37
WGK Germany  3

ANTI-CONNEXIN 43 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB4501174 Anti-Connexin 43 antibody produced in rabbit affinity isolated antibody 100μG $506 2024-03-01 Buy
Sigma-Aldrich SAB4501173 Anti-Connexin 43 antibody produced in rabbit affinity isolated antibody 100μG $506 2024-03-01 Buy
Sigma-Aldrich SAB4300504 Anti-GJA1 (Ab-367) antibody produced in rabbit affinity isolated antibody 100μG $441 2024-03-01 Buy
Sigma-Aldrich SAB4300206 Anti-phospho-GJA1 (pSer368) antibody produced in rabbit affinity isolated antibody 100μG $511 2024-03-01 Buy
Sigma-Aldrich SAB2100918 Anti-GJA1 antibody produced in rabbit affinity isolated antibody 100μL $478 2024-03-01 Buy
Product number Packaging Price Buy
SAB4501174 100μG $506 Buy
SAB4501173 100μG $506 Buy
SAB4300504 100μG $441 Buy
SAB4300206 100μG $511 Buy
SAB2100918 100μL $478 Buy

ANTI-CONNEXIN 43 Chemical Properties,Uses,Production

Uses

Anti-Connexin-43 may be used in immunoblotting, immunocytochemistry and immunohistochemistry (frozen and formalin-fixed, paraffin-embedded tissues). Polyclonal antibodies reacting specifically with Cx43 may be applied in diverse cellular and molecular approaches to the study of gap junctions and their properties.
A minimum working dilution of 1:8,000 is determined by immunoblotting using a whole extract from mouse brain.
A minimum working dilution of 1:400 is determined by indirect immunofluorescent staining of acetone-fixed cultured baby hamster kidney (BHK).
A minimum working dilution of 1:2,000 is determined by indirect immunofluorescent staining of rat heart. (Negative on rat liver sections)
A minimum working dilution of 1:2,000 is determined by indirect immunoperoxidase staining of trypsin-digested,formalin-fixed, paraffin-embedded human or animal tissue.

General Description

Monoclonal Anti-Connexin-43 (mouse IgM isotype) is derived from the CXN-6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Connexin 43 (Cx43) is also known as GJA1 (gap junction protein alpha 1). The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops and a C-terminal cytoplasmic tail of varying length.

Biochem/physiol Actions

Connexin-43 (Cx-43) might play a vital role in neuronal migration as it resides in radial glial fibers which are closely associated with migrating neurons. It is also involved in transmembrane NAD+ transport. Connexin-43, which is an element of gap junction, facilitates cell-cell communication. Cx-43 is known to induce [Ca2+]i burst phenomenon in uterine artery endothelial cells (UAECs). Elevated expression of Cx-43 has been observed during early stages of human coronary atherosclerosis. Reduction or alteration in the levels or types of connexin expressed in various cell types correlates with tumor progression and metastasis. However, glioma cells transfected with the oncogene neu (c-erb-B2) exhibit a major reduction in intercellular communication with no decrease in overall expression of Cx43. Different states of rat Cx43 phosphorylation are found during development and lactation. Connexin 43 mutations occur in children whose hearts failed to develop asymmetry and lethal heart malformations occur on knocking out this gene in mice. Polyclonal antibodies reacting specifically with Cx438-11 may be applied in diverse cellular and molecular approaches to the study of gap junctions and their properties, and to correlate their expression pattern in a variety of cell types and tissues with physiological functions or pathological conditions.

ANTI-CONNEXIN 43 Preparation Products And Raw materials

Raw materials

Preparation Products

ANTI-CONNEXIN 43 Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
ANTI-CX43 ANTI-CONNEXIN 43 Monoclonal Anti-Connexin-43 antibody produced in mouse Anti-DFNB38 Anti-Connexin-43 antibody produced in rabbit Anti-GJA1 antibody produced in goat Anti-GJAL Anti-ODDD gap junction protein, alpha 1, 43kDa Anti-CX43 antibody produced in rabbit Anti-DFNB38 antibody produced in rabbit Anti-gap junction protein, alpha 1, 43kDa antibody produced in rabbit Anti-GJA1 (Ab-367) antibody produced in rabbit Anti-GJAL antibody produced in rabbit Anti-ODDD antibody produced in rabbit Anti-Gap junction protein, α 1, 43kDa Anti-GJA1 antibody produced in rabbit Anti-phospho-GJA1 (pSer368) antibody produced in rabbit CCardiac Stem Cell Biology Alphabetical Index Antibodies to Adhesion Molecules and Related ProteinsAntibodies Antibodies to Cytoskeleton Cardiac Stem Cell Tracking Cardiogenesis MarkersAntibodies Cell Biology Clone Index CO-CZ Antibodies to Adhesion Molecules and Related ProteinsCardiac Stem Cell Biology Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell BiologyCell Biology Stem Cell Biology Stem Cell Characterization