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PAPAVERINE HYDROCHLORIDE

PAPAVERINE HYDROCHLORIDE
PAPAVERINE HYDROCHLORIDE structure
CAS No.
58-74-2
Chemical Name:
PAPAVERINE HYDROCHLORIDE
Synonyms
S-M-R;Papacon;Papaveri;Papalease;papanerin;papaverin;Robaxapap;PAPAVERINE;Papanerine;Papaverina
CBNumber:
CB4689771
Molecular Formula:
C20H22ClNO4
Formula Weight:
375.85
MOL File:
58-74-2.mol

PAPAVERINE HYDROCHLORIDE Properties

Melting point:
226 °C
Boiling point:
475.36°C (rough estimate)
Density 
d420 1.337
refractive index 
1.6250 (estimate)
solubility 
H2O: 25 mg/mL
pka
6.4(at 25℃)
form 
powder
color 
white
Water Solubility 
37.33mg/L(37.5 ºC)
Merck 
14,7019
BRN 
312930
EWG's Food Scores
1
FDA UNII
DAA13NKG2Q
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22
RIDADR  UN 1544 6.1/PG 3
WGK Germany  1
RTECS  NW8575000
8
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 orl-rat: 325 mg/kg ARZNAD 20,1338,70

PAPAVERINE HYDROCHLORIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10011133 Papaverine 58-74-2 10mg $75 2020-06-24 Buy
Cayman Chemical 10011133 Papaverine 58-74-2 100mg $225 2020-06-24 Buy
Cayman Chemical 10011133 Papaverine 58-74-2 50mg $131 2020-06-24 Buy

PAPAVERINE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder; obtained asorthorhombic prisms from an alcohol–ethermixture; melts at 147°C (296.6°F); sublimesunder vacuum; insoluble in water; soluble inacetone, glacial acetic acid, and benzene.

Uses

folate metabolic inhibitor, coccidiostat

Uses

muscle relaxant (smooth), cerebral vasodilator

Uses

opium alkaloid

Uses

Papaverine occurs in opium to the extent of0.8–1.0%, commonly associated with narcotine.It is used as a smooth muscle relaxantand in medicine for its vasodilator action onthe blood vessels in the brain. It is effectiveagainst asthma.

Definition

ChEBI: A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Indications

Papaverine (Pavabid) is a nonspecific phosphodiesterase inhibitor that increases cAMP and cGMP levels in penile erectile tissue. Papaverine is particularly known as a smooth muscle relaxant and vasodilator. Its principal pharmacological action is as a nonspecific vasodilator of smooth muscles of the arterioles and capillaries. Various vascular beds and smooth muscle respond differently to papaverine administration both in intensity and duration. Papaverine decreases the resistance to arterial inflow and increases the resistance to venous outflow.

brand name

Pavabid (Hoechst Marion Roussel).

Health Hazard

Papaverine is an inhibitor of cyclic nucleotidephosphodiesterase, producing vasodilatoryeffect. The acute toxic effects relative tophenanthrene-type opium alkaloids (e.g.,morphine, heroin) are low and the symptomsare not the same. Papaverine is neither a narcoticnor an addictive substance. Excessivedoses may produce drowsiness, headache,facial flushing, constipation, nausea, vomiting,and liver toxicity.
The LD50 data reported in the literatureshow variation. An oral LD50 value in rats ison the order of 400 mg/kg.

Clinical Use

Papaverine is highly effective in men with psychogenic and neurogenic ED but less effective in men with vasculogenic ED. Papaverine–phentolamine combinations have been used in self-injection procedures. Papaverine doses may range from 15 to 60 mg. Papaverine treatment in patients with severe arterial or venous incompetence is usually unsuccessful, but autoinjections using low doses sufficient to achieve an erection are safe and efficient.

Side effects

Major side effects associated with papaverine therapy include priapism, corporeal fibrosis, and occasional increases in serum aminotransferases. Intracorporeal scarring may be related to the low pH of the vehicle that is necessary to solubilize papaverine.Attempts to buffer papaverine to render it more suitable for intracavernosal injection have not been entirely satisfactory, and such delivery may still lead to intracorporeal scarring.

Safety Profile

Poison by ingestion, intramuscular, subcutaneous, intradermal, intraperitoneal, and intravenous routes. Human systemic effects: coma, somnolence. Its central nervous system action is about midway between those of morphme and codeine, and large doses do not produce the amount of excitement caused by codeine or the soporific action of morphine. Mutation data reported. A cerebral vasodilator and smooth muscle relaxant. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also MORPHINE.

PAPAVERINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


PAPAVERINE HYDROCHLORIDE Spectrum


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