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THAPSIGARGIN

THAPSIGARGIN
THAPSIGARGIN structure
CAS No.
67526-95-8
Chemical Name:
THAPSIGARGIN
Synonyms
THAPSIGARGIN;Thapsigargin,97%;Thapsigargin (TG);InSolution? Thapsigargin;Thapsigargin, FroM Thapsia garganica;Azuleno[4,5-b]furan octanoic acid deriv.;Thapsigargin, 99%, from Thapsia garganica;Thapsigargin - CAS 67526-95-8 - Calbiochem;Thapsigargin (Synonyms: Thapsigargin (TG));InSolution Thapsigargin - CAS 67526-95-8 - Calbiochem
CBNumber:
CB4768595
Molecular Formula:
C34H50O12
Formula Weight:
650.75
MOL File:
67526-95-8.mol

THAPSIGARGIN Properties

Boiling point:
597.77°C (rough estimate)
Density 
1.1521 (rough estimate)
refractive index 
1.6390 (estimate)
RTECS 
RH0325700
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
liquid or film
color 
Colorless
Sensitive 
Light Sensitive
CAS DataBase Reference
67526-95-8(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T
Risk Statements  36/37/38-42
Safety Statements  26-36/37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29181990
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 Wear respiratory protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

THAPSIGARGIN price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 586005 Thapsigargin 67526-95-8 1mg $119 2018-11-20 Buy
Sigma-Aldrich 586006 InSolution? Thapsigargin 67526-95-8 2mg $206 2018-11-20 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 1mg $122 2018-11-20 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 5mg $520 2018-11-20 Buy
Cayman Chemical 10522 Thapsigargin ≥97% 67526-95-8 1mg $52 2018-11-13 Buy

THAPSIGARGIN Chemical Properties,Uses,Production

Chemical Properties

THAPSIGARGIN is colourless film

Uses

THAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.

Uses

Reagent for defining and manipulating intracellular calcium pools.

Definition

THAPSIGARGIN is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargi inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.

Biological Activity

Potent inhibitor of sarco-endoplasmic reticulum Ca 2+ -ATPases.

THAPSIGARGIN Preparation Products And Raw materials

Raw materials

Preparation Products


THAPSIGARGIN Suppliers

Global( 73)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15884 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 280 60
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32365 50
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 mkt@spectrumchina.net China 9692 60
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4087 58
Thermo Fisher Scientific 800-810-5118
+86-10-84193589 cnchemical@thermofisher.com China 17448 75
Cheng Du Micxy Chemical Co.,Ltd 028-85632863 028-64559668 18048500443
028-85632863 QQ: 2509670926 micxysales@163.com China 13076 58

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