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THAPSIGARGIN

THAPSIGARGIN
THAPSIGARGIN structure
CAS No.
67526-95-8
Chemical Name:
THAPSIGARGIN
Synonyms
THAPSIGARGIN;Thapsigargin,97%;Thapsigargin (TG);InSolution? Thapsigargin;Thapsigargin, FroM Thapsia garganica;Azuleno[4,5-b]furan octanoic acid deriv.;Thapsigargin, 99%, from Thapsia garganica;Thapsigargin (Synonyms: Thapsigargin (TG));Thapsigargin - CAS 67526-95-8 - Calbiochem;InSolution Thapsigargin - CAS 67526-95-8 - Calbiochem
CBNumber:
CB4768595
Molecular Formula:
C34H50O12
Formula Weight:
650.75
MOL File:
67526-95-8.mol

THAPSIGARGIN Properties

Boiling point:
597.77°C (rough estimate)
Density 
1.1521 (rough estimate)
refractive index 
1.6390 (estimate)
RTECS 
RH0325700
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
liquid or film
pka
10.57±0.70(Predicted)
color 
Colorless
Sensitive 
Light Sensitive
CAS DataBase Reference
67526-95-8(CAS DataBase Reference)
FDA UNII
Z96BQ26RZD
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Hazard statements  H315-H319-H334-H335
Precautionary statements  P261-P280a-P284-P305+P351+P338-P405-P501a
Hazard Codes  Xn,T
Risk Statements  36/37/38-42
Safety Statements  26-36/37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29181990

THAPSIGARGIN price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 586005 Thapsigargin 67526-95-8 1mg $133 2020-08-18 Buy
Sigma-Aldrich 586006 InSolution? Thapsigargin 67526-95-8 2mg $214 2020-08-18 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 1mg $125 2020-06-24 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 5mg $536 2020-06-24 Buy
Cayman Chemical 10522 Thapsigargin ≥97% 67526-95-8 1mg $56 2020-06-24 Buy

THAPSIGARGIN Chemical Properties,Uses,Production

Chemical Properties

THAPSIGARGIN is colourless film

Uses

THAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.

Uses

Reagent for defining and manipulating intracellular calcium pools.

Definition

THAPSIGARGIN is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargi inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.

Biological Activity

Potent inhibitor of sarco-endoplasmic reticulum Ca 2+ -ATPases.

THAPSIGARGIN Preparation Products And Raw materials

Raw materials

Preparation Products


THAPSIGARGIN Suppliers

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