ChemicalBook >> CAS DataBase List >>Thapsigargin


Chemical Name:
hapsigargin;THAPSIGARGIN;Thapsigargin,97%;Thapsigargin (TG);THAPSIGARGIN USP/EP/BP;InSolution? Thapsigargin;Thapsigargin, FroM Thapsia garganica;Azuleno[4,5-b]furan octanoic acid deriv.;Thapsigargin, 99%, from Thapsia garganica;Thapsigargin - CAS 67526-95-8 - Calbiochem
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2023-05-18 11:31:12

Thapsigargin Properties

Boiling point 597.77°C (rough estimate)
Density 1.1521 (rough estimate)
refractive index 1.6390 (estimate)
RTECS RH0325700
storage temp. -20°C
solubility DMSO: soluble
form liquid or film
pka 10.57±0.70(Predicted)
color Colorless
Sensitive Light Sensitive
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
CAS DataBase Reference 67526-95-8(CAS DataBase Reference)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H315-H319-H334-H335
Precautionary statements  P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,T
Risk Statements  36/37/38-42
Safety Statements  26-36/37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29181990

Thapsigargin price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T9033 Thapsigargin ≥98% (HPLC), solid film 67526-95-8 0.5mg $121 2023-01-07 Buy
Sigma-Aldrich 586006 InSolution? Thapsigargin 67526-95-8 2mg $264 2023-01-07 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 1mg $125 2021-12-16 Buy
Alfa Aesar J62866 Thapsigargin 95% 67526-95-8 5mg $536 2021-12-16 Buy
Cayman Chemical 10522 Thapsigargin ≥97% 67526-95-8 1mg $61 2023-01-06 Buy
Product number Packaging Price Buy
T9033 0.5mg $121 Buy
586006 2mg $264 Buy
J62866 1mg $125 Buy
J62866 5mg $536 Buy
10522 1mg $61 Buy

Thapsigargin Chemical Properties,Uses,Production


Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. It is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). This tumor promoter releases Ca2+ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2+-ATPase; it does not directly affect plasma membrane Ca2+-ATPases, Ins 1,4,5-P3 production or protein kinase C activity. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis.

Chemical Properties

Thapsigargin (TG) is colourless film. It is extracted from the plant Thapsia garganica L. with methanol and purified by HPLC. TG is a tumor promoting plant sesquiterpene lactone extract with a unique biological activity as Ca2+ -ATPase inhibitors in animal cells. It is a skin irritant, a platelet activating, inflammatory and tumor promoting agent. TG is toxic and a possible carcinogen.


THAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.


ChEBI: Thapsigargin is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. It has a role as an EC (Ca(2+)-transporting ATPase) inhibitor and a calcium channel blocker. It is a sesquiterpene lactone, an organic heterotricyclic compound and a butyrate ester.

Biochem/physiol Actions

Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. The inhibition of calcium ion pumps causes intracellular increase of calcium ion levels. It was found that thapsigargin at 100 nM concentration effectively inhibited the SR Ca2+- adenosine triphosphatase (ATPase) in cardiac and skeletal muscles. Thapsigargin was also reported to be effective in blocking autophagy by interfering with the autophagosome-lysosome fusion.

Mode of action

The actual mechanism of action of thapsigargin is thought actually to block calcium channels in an open conformation that results in excess calcium entry from outside the cell. Excess calcium activates DNAses and precipitates the natural death sequence of the cells.Scientists are now thinking of modifying thapsigargin in such a way thatit will kill prostate cells preferentially and will not penetrate healthy cells elsewhere in the body.At the same time, they are determining whether this drug can also induce cell death in breast cancer cells.


1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131 2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596

Thapsigargin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 138)Suppliers
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0371-55170695 CHINA 26700 58
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Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763 China 25363 58

View Lastest Price from Thapsigargin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
US $1.00 / g 1g 85.0-99.8% 20tons Career Henan Chemica Co
  • THAPSIGARGIN pictures
  • US $1.00 / g
  • 85.0-99.8%
  • Career Henan Chemica Co
THAPSIGARGIN Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate Octanoic acid [(3S)-6α-acetoxy-2,3,3a,4,5,6,6aα,7,8,9bβ-decahydro-3β,3aα-dihydroxy-3,6,9-trimethyl-8β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4β-(1-oxobutoxy)azuleno[4,5-b]furan]-7α-yl ester Thapsigargin,97% Octanoic Acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[[(2Z)-2-Methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester Octanoic Acid [3S-[3α,3aβ,4α,6β,6aβ,7β,8α(Z),9bα]]-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[(2-Methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester Thapsigargin (TG) Thapsigargin, FroM Thapsia garganica Azuleno[4,5-b]furan octanoic acid deriv. Thapsigargin Azuleno[4,5-b]furan octanoic acid deriv InSolution? Thapsigargin Thapsigargin, 99%, from Thapsia garganica Thapsigargin - CAS 67526-95-8 - Calbiochem InSolution Thapsigargin - CAS 67526-95-8 - Calbiochem Thapsigargin (Synonyms: Thapsigargin (TG)) THAPSIGARGIN USP/EP/BP (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3... (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate [(3S,3aR,4S,6S,6aS,7S,8S,9bR)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-(2-methylbut-2-enoyloxy)-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate hapsigargin 67526-95-8 C34H50O12 BioChemical Cell Signaling and Neuroscience Cell Biology Intracellular Calcium Regulators Intracellular Calcium Signaling plantgrowth Adenosinetriphosphatase (microsomal calcium)Cell Signaling and Neuroscience Antitumor Agents Intracellular Calcium RegulatorsCancer Research Intracellular Calcium Signaling Therapy Adjuncts A to Enzyme Inhibitors by Enzyme Calcium signaling Signalling Apoptosis Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals