1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-
![1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- Structure](CAS/20210305/GIF/909561-15-5.gif)
- CAS No.
- 909561-15-5
- Chemical Name:
- 1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-
- Synonyms
- AS1810722;AS1810722, 10 mM in DMSO;2-(4-(4-((7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)acetamide;1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-;AS-1810722,inhibit,CYPs,AS 1810722,Cytochrome P450,eosinophil,allergic,AS1810722,STAT,orally,Inhibitor,asthma,IL-4,infiltration,IFN-γ
- CBNumber:
- CB48650663
- Molecular Formula:
- C25H25F2N7O
- Molecular Weight:
- 477.51
- MDL Number:
- MOL File:
- 909561-15-5.mol
1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- Properties
| Boiling point | 731.4±70.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 62.5 mg/mL (130.89 mM) |
| pka | 16.30±0.40(Predicted) |
| form | Solid |
| color | Brown to black |
1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0148749 | AS1810722 | 909561-15-5 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0148749 | AS1810722 | 909561-15-5 | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0148749 | AS1810722 | 909561-15-5 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0148749 | AS1810722 | 909561-15-5 | 50mg | $1450 | 2021-12-16 | Buy |
| ChemScene | CS-0148749 | AS1810722 | 909561-15-5 | 100mg | $2250 | 2021-12-16 | Buy |
1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- Chemical Properties,Uses,Production
Uses
AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research[1].
in vivo
AS1810722 (compound 24; 0.03-0.3 mg/kg; orally; 30 min before, and 24h and 48 h after OVA exposure) suppress eosinophil infiltration in the lung in a dose-dependent manner in an antigen-induced mouse asthmatic model[1].
?
AS1810722 inhibits in vitro Th2 differentiation with an IC50 of 2.4 nM without affecting type 1 helper T (Th1) cell differentiation and eosinophil infiltration in an antigen-induced mouse asthmatic model after oral administration[1].
| Animal Model: | Female Balb/c mice asthmatic model by intraperitoneal injection of ovalbumin (OVA)-containing aluminum hydroxide gel[1] |
| Dosage: | 0.03-0.3 mg/kg |
| Administration: | Orally; 30 min before, and 24 and 48 h after OVA exposure |
| Result: | Suppressed eosinophil infiltration in the lung in a dose-dependent manner. |
IC 50
STAT6: 1.9 nM (IC50); CYP3A4
References
[1] Shinya Nagashima, et al. Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. Bioorg Med Chem. 2009 Oct 1;17(19):6926-36. DOI:10.1016/j.bmc.2009.08.021
1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4951 | 55 |
| Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9857 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62321 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24890 | 58 |
