ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
- CAS No.
- 170858-33-0
- Chemical Name:
- Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
- Synonyms
- U 101387;PNU 101387;PF-05191680;PNU-101387G;Sonepiprazole;Sonepiprazole hydrate;inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor;4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate;(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide;4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide
- CBNumber:
- CB51245409
- Molecular Formula:
- C21H27N3O3S
- Molecular Weight:
- 401.52
- MDL Number:
- MFCD05662325
- MOL File:
- 170858-33-0.mol
- MSDS File:
- SDS
Last updated:2023-09-04 15:51:00
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Properties
storage temp. | room temp |
---|---|
solubility | DMSO: >10mg/mL |
form | powder |
color | white to off-white |
FDA UNII | O609V24217 |
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PZ0174 | Sonepiprazole hydrate ≥98% (HPLC) | 170858-33-0 | 5mg | $117 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0174 | Sonepiprazole hydrate ≥98% (HPLC) | 170858-33-0 | 25mg | $426 | 2024-03-01 | Buy |
Cayman Chemical | 11983 | Sonepiprazole ≥98% | 170858-33-0 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 11983 | Sonepiprazole ≥98% | 170858-33-0 | 5mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 11983 | Sonepiprazole ≥98% | 170858-33-0 | 10mg | $193 | 2024-03-01 | Buy |
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Chemical Properties,Uses,Production
Description
Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.
Uses
Sonepiprazole is a dopamine D4 antagonist with Ki=10 nM.
storage
Store at +4°C
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 54)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | SALES@UHNSHANGHAI.COM | China | 977 | 58 |
Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9798 | 50 |
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Spectrum
(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide
4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide
PF-05191680
PNU 101387
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
U 101387
Sonepiprazole
4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate
PNU-101387G
Sonepiprazole hydrate
Benzenesulfonamide, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-
inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor
170858-33-0
70858-33-0
Aromatics
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pfizer Compounds
Pharmaceuticals
Sulfur & Selenium Compounds