ChemicalBook >> CAS DataBase List >>1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- structure

CAS No.: 2097610-30-3

Chemical Name:: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-

Synonyms: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-

CBNumber:: CB513181773

Molecular Formula:: C23H19N3O4

Molecular Weight:: 401.41

MDL Number:

MOL File:: 2097610-30-3.mol

Last updated:2025-04-18 09:52:24

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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- Properties

Density	1.431±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 5mg/mL, clear (warmed)
pka	11.76±0.30(Predicted)
form	powder
color	white to light brown
UNSPSC Code	12352200
NACRES	NA.77

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- Chemical Properties,Uses,Production

Uses

BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 μM, 10.4 μM and 10.0 μM respectively[1].

Biological Activity

BAY-364 (BAY-299N) is structurally similar to selective BRD1/TAF1 inhibitor BAY-299 and serves as inactive control. BAY-364 is inactive against BRD1 and exhibit moderate activity against TAF1 (3 μM). For full characterization details of the active probe, please visit the BAY-299 probe summary on the Structural Genomics Consortium (SGC) website.

BAY-299, the active probe, is available from Sigma. To learn more about and purchase BAY-299, click here.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

References

[1] Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10(1):4925. DOI:10.1038/s41467-019-12735-z
[2] Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29243	58
Merck KGaA	21-20338288	ordercn@merckgroup.com	China	6394	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Merck KGaA	58

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1-methyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)- 2097610-30-3