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Macromerine

Macromerine Structure
Macromerine structure
CAS No.
19751-75-8
Chemical Name:
Macromerine
Synonyms
Macromerine;[R,(-)]-α-[(Dimethylamino)methyl]-3,4-dimethoxybenzenemethanol;Benzenemethanol, α-[(dimethylamino)methyl]-3,4-dimethoxy-, (αR)-
CBNumber:
CB51457929
Molecular Formula:
C12H19NO3
Molecular Weight:
225.28
MDL Number:
MOL File:
19751-75-8.mol
Last updated:2022-12-21 16:56:50
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Macromerine Properties

Melting point 66-67.SoC
FDA UNII 5V42VYT1D6

Macromerine Chemical Properties,Uses,Production

Description

Hodgkins and his co-workers have isolated this alkaloid from Coryphantha macromeris (Engelm.) Lem. Britton and Rose (Syn. Thelocactus macromeris (Engelm.) L. Benson and it has subsequently been discovered in C. runyonii. It is a laevorotatory base with [α]25D - 42.61° (c 2.0, EtOH) or - 147.01° (c 3.9, CHC13). The synthetic (±)-form has a higher m.p. l46-7°C and yields a crystalline picrate, m.p. 147°C. Spectroscopic and chemical data are in accord with the structure (-)- -(3 :4-dimethoxyphenyl)- -(dimethylamino)ethanol.

References

Hodgkins, Brown, Massingill., Tetrahedron Lett., 1321 (1967) Below et al., J. Pharm. Sci., 57,515 (1968)

Macromerine Preparation Products And Raw materials

Raw materials

Preparation Products

Macromerine [R,(-)]-α-[(Dimethylamino)methyl]-3,4-dimethoxybenzenemethanol Benzenemethanol, α-[(dimethylamino)methyl]-3,4-dimethoxy-, (αR)- 19751-75-8 Benzene series