BZ-TYR-4-ABZ-OH
- CAS No.
- 37106-97-1
- Chemical Name:
- BZ-TYR-4-ABZ-OH
- Synonyms
- btpaba;chymex;e-2663;BTPABA,PFT;BENTIROMIDE;BZ-TYR-4-ABZ-OH;BentiroMide, BTPABA;benzoyltyrosyl-p-aminobenzoicacid;N-Benzoyl-L-tyrosyl-p-aminobenzoate;n-benzoyl-l-tyrosyl-p-aminobenzoicacid
- CBNumber:
- CB5161221
- Molecular Formula:
- C23H20N2O5
- Molecular Weight:
- 404.42
- MDL Number:
- MFCD00055768
- MOL File:
- 37106-97-1.mol
- MSDS File:
- SDS
| Melting point | 240-242° |
|---|---|
| alpha | D25 +72.3° (c = 1 in DMF) (US 3801562); D25 +87° (c = 1 in DMF) (De Benneville) |
| Boiling point | 526.04°C (rough estimate) |
| Density | 1.3093 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Store at RT. |
| solubility | DMSO:250.0(Max Conc. mg/mL);618.17(Max Conc. mM) |
| pka | 4.27±0.10(Predicted) |
| FDA UNII | 239IF5W61J |
| ATC code | V04CK03 |
BZ-TYR-4-ABZ-OH price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265226 | Bz-Tyr-4-Abz-OH | 37106-97-1 | 500mg | $213 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB49255 | Bz-Tyr-4-Abz-OH | 37106-97-1 | 1g | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB49255 | Bz-Tyr-4-Abz-OH | 37106-97-1 | 2g | $400 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004601 | BENTIROMIDE 95.00% | 37106-97-1 | 5MG | $403.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004601 | BENTIROMIDE 95.00% | 37106-97-1 | 250MG | $570 | 2021-12-16 | Buy |
BZ-TYR-4-ABZ-OH Chemical Properties,Uses,Production
Originator
PFD Oral Sol,Eisai,Japan,1980
Uses
Diagnostic aid (pancreas function determination).
Definition
ChEBI: The dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic t erapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
Manufacturing Process
A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g,
0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the
mixture was cooled to room temperature, and the precipitate of tyrosine
hydrochloride filtered off (11 g, 46 meq. Cl-). The THF was evaporated and
the residue extracted with CCl4 (3 X 100 ml at reflux, discarded) and then
dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate
solution was evaporated to yield 132 g solid product, MP 159°-162°C (93%).
The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from
the hydrochloride.
A solution was made of N-benzyl-L-tyrosine (5.7 g, 20 mmols) and Nmethylmorpholine (2.04 g, 20 mmols) in 60 ml of THF, at -15°C, and to it was
added ethyl chloroformate (2.08 g, 20 mmols). After 12 minutes, paminobenzoic acid (2.74 g, 20 mmols) dissolved in 25 ml of THF and 0.38 g of
p-toluenesulfonic acid (2 mmols) were added, and the temperature allowed to
rise to 5°C. After 2 hours and forty minutes, the mixture was poured into l
liter of 0.1 N cold HCl, stirred one-half hour, filtered and dried, to give 8,7 g,
MP 192°-223°C. The product was recrystallized from 90 ml methanol and 40
ml water, to give 6 g (74%) of product, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, MP 240°-242°C.
brand name
Chymex (Savage).
Therapeutic Function
Diagnostic aid (pancreatic function)
BZ-TYR-4-ABZ-OH Preparation Products And Raw materials
BZ-TYR-4-ABZ-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-021-64543801 13764082696 | 2355241799@qq.com | China | 42982 | 64 |
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