Arginase inhibitor 1
- CAS No.
- 1345808-25-4
- Chemical Name:
- Arginase inhibitor 1
- Synonyms
- Arginase inhibitor 1;1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-;(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid
- CBNumber:
- CB52677054
- Molecular Formula:
- C13H27BN2O4
- Molecular Weight:
- 286.18
- MDL Number:
- MFCD28167713
- MOL File:
- 1345808-25-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Arginase inhibitor 1 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28418 | Arginase Inhibitor 1 | 1345808-25-4 | 1mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 28418 | Arginase Inhibitor 1 | 1345808-25-4 | 5mg | $684 | 2024-03-01 | Buy |
| AK Scientific | 1379DT | Arginaseinhibitor1 | 1345808-25-4 | 5mg | $860 | 2021-12-16 | Buy |
| ChemScene | CS-1736 | Arginaseinhibitor1 98.00% | 1345808-25-4 | 10mg | $504 | 2021-12-16 | Buy |
| ApexBio Technology | B1009 | Arginaseinhibitor1 | 1345808-25-4 | 10mg | $662 | 2021-12-16 | Buy |
Arginase inhibitor 1 Chemical Properties,Uses,Production
Description
Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.
Uses
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.
in vivo
Following i.v. dosing with 10 mg/kg in fasted animals, Arginase inhibitor 1has a terminal elimination half-life (t1/2) of 3.3 h with a volume of distribution and total body clearance of 1.86 L/kg and 7.89 mL/min/kg, respectively. The oral bioavailability of Arginase inhibitor 1 (10 mg/kg, p.o.) is 28% with a Cmax of 0.45 mg/L[1].
References
[1] Van Zandt MC, et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potentinhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80. DOI:10.1021/jm400014c
Arginase inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Arginase inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
View Lastest Price from Arginase inhibitor 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Arginase inhibitor 1
1345808-25-4
|
US $1710.00-383.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Arginase inhibitor 1
1345808-25-4
- US $1710.00-383.00 / mg
- TargetMol Chemicals Inc.