ChemicalBook >> CAS DataBase List >>AZD-5069
AZD-5069
- CAS No.
- 878385-84-3
- Chemical Name:
- AZD-5069
- Synonyms
- CS-2808;AZD-5069;CPDD1543;ACT-281959;AZD 5069; AZD5069;AZD-5069; AZD 5069; AZD5069;878385-84-3;inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide;1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-;N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide
- CBNumber:
- CB52702941
- Molecular Formula:
- C18H22F2N4O5S2
- Molecular Weight:
- 476.52
- MDL Number:
- MFCD31631376
- MOL File:
- 878385-84-3.mol
Last updated:2023-05-18 11:31:08
| Melting point | 149-152°C |
|---|---|
| Boiling point | 680.5±65.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.56±0.20(Predicted) |
| color | White to Off-White |
| FDA UNII | 4ADT8JXB9S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501 |
| HS Code | 2935909099 |
AZD-5069 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28297 | AZD 5069 | 878385-84-3 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 28297 | AZD 5069 | 878385-84-3 | 25mg | $515 | 2024-03-01 | Buy |
| Cayman Chemical | 28297 | AZD 5069 | 878385-84-3 | 5mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 28297 | AZD 5069 | 878385-84-3 | 10mg | $238 | 2024-03-01 | Buy |
| TRC | A965309 | AZD-5069 | 878385-84-3 | 5mg | $130 | 2021-12-16 | Buy |
AZD-5069 Chemical Properties,Uses,Production
Description
AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment.
Uses
AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions.
Biological Activity
AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.
AZD-5069 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 62)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
AZD-5069
ACT-281959
CPDD1543
AZD 5069; AZD5069
CS-2808
AZD-5069; AZD 5069; AZD5069;878385-84-3
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-
N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide
inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors
878385-84-3
C18H22F2N4O5S2
APIs