ITD-1
- CAS No.
- 1099644-42-4
- Chemical Name:
- ITD-1
- Synonyms
- ITD-1;CS-1731;AOB6123;SCHEMBL3239096;ITD1;ITD-1;ITD 1;inhibit,Transforming growth factor beta receptors,ITD 1,TGF-β Receptor,ITD1,ITD-1,Inhibitor;ETHYL 4-{[1,1'-BIPHENYL]-4-YL}-2,7,7-TRIMETHYL-5-OXO-1,4,6,8-TETRAHYDROQUINOLINE-3-CARBOXYLATE;Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
- CBNumber:
- CB52714670
- Molecular Formula:
- C27H29NO3
- Molecular Weight:
- 415.52
- MDL Number:
- MFCD28133391
- MOL File:
- 1099644-42-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H410 |
| Precautionary statements | P501-P273-P260-P270-P262-P271-P264-P280-P284-P391-P361+P364-P301+P310+P330-P302+P352+P310-P304+P340+P310-P403+P233-P405 |
ITD-1 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23326 | ITD 1 ≥98% | 1099644-42-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 23326 | ITD 1 ≥98% | 1099644-42-4 | 10mg | $146 | 2024-03-01 | Buy |
| Cayman Chemical | 23326 | ITD 1 ≥98% | 1099644-42-4 | 25mg | $321 | 2024-03-01 | Buy |
| Cayman Chemical | 23326 | ITD 1 ≥98% | 1099644-42-4 | 50mg | $593 | 2024-03-01 | Buy |
| Tocris | 5068 | ITD1 ≥98%(HPLC) | 1099644-42-4 | 50 | $952 | 2021-12-16 | Buy |
ITD-1 Chemical Properties,Uses,Production
Uses
ITD-1 is a selective inhibitor of TGF-β signaling and induces cardiomyocyte differentiation in embryonic stem cells (ESCs).
Biological Activity
tgfβ signalling has been shown to be important at an early stage in cardiac development, with most previous investigations focussing on the role during formation of the cardiac cushions. these cushions, which develop between embryonic day e9.5 and e11.5 in the mouse, are essential precursors of the mature valves, and intimately involved in septation. it is well known that tgfβ signalling promotes endothelial to mesenchymal transition, and subsequent migration of mesenchymal cells to the cardiac jelly. itd-1 is the first selective tgfβ inhibitor.
in vitro
itd-1 has been used to evaluate tgfβ involvement in mesoderm formation and cardiopoietic differentiation, which occur sequentially during early development, indicating an essential role in both processes in esc cultures. itd-1 selectively enhanced the uncommitted mesoderm differentiation to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. in summary, itd-1 is the first selective tgfβ inhibitor and reveals an unexpected role for tgfβ signaling in controlling the differentiation of cardiomyocyte from multipotent cardiovascular precursors [1].
storage
+4°C
References
[1] willems e, cabral-teixeira j, schade d, cai w, reeves p, bushway pj, lanier m, walsh c, kirchhausen t, izpisua belmonte jc, cashman j, mercola m. small molecule-mediated tgf-β type ii receptor degradation promotes cardiomyogenesis in embryonic stem cells. cell stem cell. 2012 aug 3;11(2):242-52.
ITD-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
