JT010
- CAS No.
- 917562-33-5
- Chemical Name:
- JT010
- Synonyms
- JT010;2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide;2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide;Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-;JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010
- CBNumber:
- CB53386492
- Molecular Formula:
- C16H19ClN2O3S
- Molecular Weight:
- 354.85
- MDL Number:
- MFCD08899142
- MOL File:
- 917562-33-5.mol
- MSDS File:
- SDS
JT010 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1672 | JT010 ≥98% (HPLC) | 917562-33-5 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1672 | JT010 ≥98% (HPLC) | 917562-33-5 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 29732 | JT010 | 917562-33-5 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 29732 | JT010 | 917562-33-5 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 29732 | JT010 | 917562-33-5 | 10mg | $166 | 2024-03-01 | Buy |
JT010 Chemical Properties,Uses,Production
Description
JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM.
Uses
JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).
Biochem/physiol Actions
JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM).
storage
Store at +4°C
JT010 Preparation Products And Raw materials
Raw materials
Preparation Products
JT010 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 17988 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2983 | 58 |