L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1)
- CAS No.
- 1606994-55-1
- Chemical Name:
- L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1)
- Synonyms
- RX-31 TFA;SS-31 TFA);MTP-131 (TFA);Elamipretide TFA;Elamipretide TFA (MTP-131 TFA;ELAMIPRETIDE TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA);L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1);(S)-6-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide 2,2,2-trifluoroacetate
- CBNumber:
- CB54657997
- Molecular Formula:
- C34H50F3N9O7
- Molecular Weight:
- 753.83
- MDL Number:
- MFCD31746869
- MOL File:
- 1606994-55-1.mol
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1) Properties
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| Water Solubility | Soluble in Water |
| InChIKey | WLZHRKGRZBGUJU-PMZDVTNTNA-N |
| SMILES | C(F)(F)(F)C(=O)O.[C@@H](NC(=O)[C@H](N)CCCNC(N)=N)(C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N)CC1C=CC=CC=1)CC1C(=CC(O)=CC=1C)C |&1:7,11,23,32,r| |
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1) Chemical Properties,Uses,Production
Description
Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide[1]. Cardiolipin peroxidase[1]
Uses
Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2].
in vivo
Elamipretide TFA (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1].
| Animal Model: | LPS-induced cognitive impairment in C57BL/6 mice model[1] |
| Dosage: | 5 mg/kg |
| Administration: | i.p., once daily for 3 days |
| Result: | Maintained the mitochondrial function, ROS and MDA levels, and SOD activity. Inhibited neural cell apoptosis in hippocampus, enhanced the hippocampal BDNF pathway and synaptic structural complexity. |
References
[1]. Sabbah HN et al. Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure. Circ Heart Fail. 2016 Feb;9(2):e002206.
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, 2,2,2-trifluoroacetate (1:1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19654 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +852-852-95427495 +85295427495 | kathy@hbyinsheng.com | China | 3512 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Hybio Pharmaceutical Co., Ltd. | +86-18964595316 | sales1@hybio.com.cn | China | 361 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7222 | 58 |
| Hangzhou Peptide Biochem Co.,Ltd | 0571-89197072; 18668118770 | linda@peptide-china.com | China | 248 | 56 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4800 | 58 |