ChemicalBook >> CAS DataBase List >>943319-87-7

943319-87-7

943319-87-7 structure

CAS No.: 943319-87-7

Chemical Name:: 943319-87-7

Synonyms: AP24567;AP-24567;Ponatinib N-Desmethyl;N-Desmethyl ponatinib;Ponatinib N-Desmethyl Analog;Ponatinib Active Metabolite A;Ponatinib Active Metabolite AP24567(M42);Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(1-piperazinylmethyl)-3-(trifluoromethyl)phenyl]-

CBNumber:: CB54660663

Molecular Formula:: C28H25F3N6O

Molecular Weight:: 518.53

MDL Number:

MOL File:: 943319-87-7.mol

Last updated:2023-05-15 10:43:39

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943319-87-7 Properties

Density	1.32±0.1 g/cm3(Predicted)
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	12.99±0.70(Predicted)
color	Pale Yellow to Light Yellow
FDA UNII	5EMP4AZ4U5

943319-87-7 Chemical Properties,Uses,Production

Uses

Ponatinib Active Metabolite AP24567(M42) is a research reagent applied in pharmaceuticals and cancer treatment. Ponatinib Active Metabolite AP24567(M42) is an analog of Ponatinib (P688250) which is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib (P688250) is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.

943319-87-7 Preparation Products And Raw materials

Raw materials

Preparation Products

943319-87-7 Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9911	50
Nanjing XiZe Biotechnology CO., Ltd.	025-58362220 15250997978	1511893459@qq.com	China	7715	55
TOSUN PHARM	020-61855200 13326451905	2881290884@qq.com	China	7487	58
Beijing xinyanhui pharmaceutical research and development co., LTD	13969155946	1461866103@qq.com	China	16111	58
Taizhou Nanfeng Pharmaceutical Research Institute	12345678910	nanfengdrug@163.com	China	15323	58
QUALITY CONTROL SOLUTIONS LTD.	13670046396	ORDERS@QCSRM.COM	China	18810	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
Nanjing Huanuo Biomedical Technology Co., Ltd	18913906212	2885426135@qq.com	China	6427	58
Henan Vcommend Consultrading Co., Ltd.	13393721940	sales@vcommend.com	China	9773	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Kewel Chemical Co., Ltd.	50
Nanjing XiZe Biotechnology CO., Ltd.	55
TOSUN PHARM	58
Beijing xinyanhui pharmaceutical research and development co., LTD	58
Taizhou Nanfeng Pharmaceutical Research Institute	58
QUALITY CONTROL SOLUTIONS LTD.	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Nanjing Huanuo Biomedical Technology Co., Ltd	58
Henan Vcommend Consultrading Co., Ltd.	58

N-Desmethyl ponatinib Ponatinib N-Desmethyl Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(1-piperazinylmethyl)-3-(trifluoromethyl)phenyl]- Ponatinib Active Metabolite AP24567(M42) AP24567 AP-24567 Ponatinib Active Metabolite A Ponatinib N-Desmethyl Analog 943319-87-7