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MGV354

MGV354 Structure
MGV354 structure
CAS No.
1852495-86-3
Chemical Name:
MGV354
Synonyms
MGV354;ID-65-CW69;(Rac)-MGV354;MGV354|MGV 354;(Rac)-MGV354, 10 mM in DMSO;pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular;1-[6-(3-{[4-(1-cyclopropanecarbonylpiperidin-4-yl)-2-methylphenyl]amino}-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxylic acid
CBNumber:
CB54668179
Molecular Formula:
C35H37N5O3
Molecular Weight:
575.71
MDL Number:
MFCD32664441
MOL File:
1852495-86-3.mol
Last updated:2025-12-07 19:09:50
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MGV354 Properties

Boiling point 824.8±65.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
solubility DMSO : 100 mg/mL (173.70 mM; Need ultrasonic)
pka 3.20±0.25(Predicted)
form Solid
color White to off-white

MGV354 Chemical Properties,Uses,Production

Uses

(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].

Biological Activity

(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].

References

[1]. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570.

MGV354 Preparation Products And Raw materials

Raw materials

Preparation Products

MGV354 Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4778 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
BOC Sciences 65
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from MGV354 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Rac)-MGV354 pictures 2025-12-05 (Rac)-MGV354
1852495-86-3
 US $42.00-167.00 / mg 99.26% 10g TargetMol Chemicals Inc.
(Rac)-MGV354 pictures 2025-12-05 (Rac)-MGV354
1852495-86-3
 US $42.00-167.00 / mg 99.26% 10g TargetMol Chemicals Inc.
  • (Rac)-MGV354 pictures
  • (Rac)-MGV354
    1852495-86-3
  • US $42.00-167.00 / mg
  • 99.26%
  • TargetMol Chemicals Inc.
  • (Rac)-MGV354 pictures
  • (Rac)-MGV354
    1852495-86-3
  • US $42.00-167.00 / mg
  • 99.26%
  • TargetMol Chemicals Inc.

MGV354 Spectrum

MGV354(1852495-86-3)1HNMR
MGV354 (Rac)-MGV354 pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular MGV354|MGV 354 1-[6-(3-{[4-(1-cyclopropanecarbonylpiperidin-4-yl)-2-methylphenyl]amino}-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxylic acid (Rac)-MGV354, 10 mM in DMSO ID-65-CW69 1852495-86-3