ARE Activator, BTZO-1 - Calbiochem

CAS No.
Chemical Name:
ARE Activator, BTZO-1 - Calbiochem
Synonyms
ARE Activator, BTZO-1 - Calbiochem
CBNumber:
CB54816880
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

ARE Activator, BTZO-1 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (Kd = 68.6 nM and 157 nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30 μM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330 nM) from apoptotic death upon serum deprivation or DOX (200 nM; Cat. No. 324380) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner.

ARE Activator, BTZO-1 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

ARE Activator, BTZO-1 - Calbiochem Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
ARE Activator, BTZO-1 - Calbiochem