InSolution SB 203580 - Calbiochem
- CAS No.
- Chemical Name:
- InSolution SB 203580 - Calbiochem
- Synonyms
- InSolution SB 203580 - Calbiochem
- CBNumber:
- CB54817382
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
InSolution SB 203580 - Calbiochem price More Price(1)
InSolution SB 203580 - Calbiochem Chemical Properties,Uses,Production
General Description
A highly specific, cell-permeable inhibitor of p38 kinase (IC50 = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 μM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
Biochem/physiol Actions
Cell permeable: yes
InSolution SB 203580 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
InSolution SB 203580 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
InSolution SB 203580 - Calbiochem