Avadomide hydrochloride
- CAS No.
- 1398053-45-6
- Chemical Name:
- Avadomide hydrochloride
- Synonyms
- CC 122 HCl;Avadomide HCl;CC122, Avadomide HCl;Avadomide hydrochloride
- CBNumber:
- CB54848227
- Molecular Formula:
- C14H15ClN4O3
- Molecular Weight:
- 322.75
- MDL Number:
- MOL File:
- 1398053-45-6.mol
| FDA UNII | 6CX4AEX3KR |
|---|
Avadomide hydrochloride Chemical Properties,Uses,Production
Uses
Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities[1][2][3].
References
[1] Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98. DOI:10.1158/1078-0432.CCR-18-1203
[2] Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89. DOI:10.1182/blood-2015-02-628669
[3] Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. DOI:10.1007/s00280-023-04531-w
Avadomide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Avadomide hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7941 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
View Lastest Price from Avadomide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Avadomide HCl
1398053-45-6
|
US $1980.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Avadomide HCl
1398053-45-6
- US $1980.00-1520.00 / mg
- TargetMol Chemicals Inc.
