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NSC135784
- CAS No.
- 74578-01-1
- Chemical Name:
- NSC135784
- Synonyms
- Thaspine HCl;Thaspine HCl, NSC 135784
- CBNumber:
- CB55493266
- Molecular Formula:
- C22H23NO8
- Molecular Weight:
- 429.43
- MDL Number:
- MOL File:
- 74578-01-1.mol
Last updated:2023-03-31 09:12:58
NSC135784 Chemical Properties,Uses,Production
Description
Thaspine, also known as NSC 135784, is a natural compound and a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.
NSC135784 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC135784 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
Thaspine HCl
Thaspine HCl, NSC 135784
74578-01-1