ChemicalBook >> CAS DataBase List >>3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
- CAS No.
- 646530-37-2
- Chemical Name:
- 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
- Synonyms
- GBL-5g;UGL-5g;UTL-5g;N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-;liver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,toxicity,hepatotoxicity,anti-inflammatory,TNF Receptor,UTL 5g,UTL5g,TNFR,UTL-5g
- CBNumber:
- CB58146679
- Molecular Formula:
- C11H8Cl2N2O2
- Molecular Weight:
- 271.1
- MDL Number:
- MFCD08724989
- MOL File:
- 646530-37-2.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:11
| Boiling point | 336.2±42.0 °C(Predicted) |
|---|---|
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 9.45±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | BL421NQ9XM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- Chemical Properties,Uses,Production
Biological Activity
UTL-5g (GBL-5g) is an anti-inflammatory TNF-α inhibitor with chemoprotective and hepatic radioprotective effects. It reduces cisplatin-induced hepatotoxicity, nephrotoxicity and bone marrow toxicity by inhibiting factors such as TNF-α.
in vitro
RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.
in vivo
UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; po; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.
| Animal Model: | C57BL/6, male mice (8-10 weeks) |
| Dosage: | 15, 30, and 60 mg/kg | < /tr>
| Administration: | Ip; before irradiation, daily x 5 |
| Result: | Blood levels of TGF-β were lowered. |
| Animal Model: | BDF1 female mice |
| Dosage: | Po; daily for 4 days |
| Administration: | 60 mg/kg (30 min before ip injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0) |
| Result: | Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death. |
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- Suppliers
Global( 20)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
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| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4182 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
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| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 165 | 58 |
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
UTL-5g
UGL-5g
GBL-5g
liver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,toxicity,hepatotoxicity,anti-inflammatory,TNF Receptor,UTL 5g,UTL5g,TNFR,UTL-5g
N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide
646530-37-2