ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-

CAS No.
2407860-35-7
Chemical Name:
2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-
Synonyms
ErSO;ErSo-DFP;(R)-3-(4-hydroxyphenyl)-3-(4-(trifluoromethoxy)phenyl)-7-(trifluoromethyl)indolin-2-one;2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-
CBNumber:
CB59803533
Molecular Formula:
C22H13F6NO3
Molecular Weight:
453.33
MDL Number:
MOL File:
2407860-35-7.mol
Last updated:2024-07-02 08:55:12

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- Properties

Boiling point 485.0±45.0 °C(Predicted)
Density 1.461±0.06 g/cm3(Predicted)
pka 9?+-.0.30(Predicted)
form Solid
color White to off-white

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- Chemical Properties,Uses,Production

Description

ErSO is an activator of the unfolded protein response which eradicates human breast tumors in mice. ErSO activates the anticipatory unfolded protein response (a-UPR) and induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. In multiple orthotopic models, ErSO treatment given either orally or intraperitoneally for 14 to 21 days induced tumor regression without recurrence. In a cell line tail vein metastasis model, ErSO was also effective at inducing regression of most lung, bone, and liver metastases. ErSO treatment induced almost complete regression of brain metastases in mice carrying intracranial human breast cancer cell line xenografts.

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 13980902949; market@dingdangchem.com China 1846 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
Beijing Yusheng Chemical Co., Ltd. 17777863707 17777863707@189.cn China 496 58
Suzhou Haiben Pharmaceutical Co., Ltd 14760821013 14760821013 1816280386@qq.com China 6689 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28070 58

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- Spectrum

2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)- ErSo-DFP ErSO (R)-3-(4-hydroxyphenyl)-3-(4-(trifluoromethoxy)phenyl)-7-(trifluoromethyl)indolin-2-one 2407860-35-7