Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]-

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]-

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- Structure
2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- structure
CAS No.
1637394-01-4
Chemical Name:
2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]-
Synonyms
GDC-0134;2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]-
CBNumber:
CB610415966
Molecular Formula:
C19H20F4N6O2
Molecular Weight:
440.39
MDL Number:
MOL File:
1637394-01-4.mol
Last updated:2025-04-18 09:51:14
Request For Quotation

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- Properties

Boiling point 626.3±65.0 °C(Predicted)
Density 1.54±0.1 g/cm3(Predicted)
form Solid
pka 5.93±0.50(Predicted)
FDA UNII 4N6KQ7D685

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- Chemical Properties,Uses,Production

Uses

GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS)[1].

References

[1] Jonathan S Katz, et al. A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66. DOI:10.1002/acn3.51491

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+8618791163155 18791163155@163.com China 3397 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3506 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 310 55
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 13186333400 cuichengbio@163.com China 4838 58
Supplier Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai XingMo Biotechnology Co., Ltd. 55
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
GDC-0134 2-Pyridinamine, 3-(difluoromethoxy)-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]- 1637394-01-4 C19H20F4N6O2