ChemicalBook >> CAS DataBase List >>MM-589 Tfa
MM-589 Tfa
- CAS No.
- 2253167-09-6
- Chemical Name:
- MM-589 Tfa
- Synonyms
- N-[(3R,6S,9S,12R)-6-ethyl-12-methyl-9-{3-[(E)-N''-methylcarbamimidamido]propyl}-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl]-2-methylpropanamide
- CBNumber:
- CB610710069
- Molecular Formula:
- C28H44N8O5.C2HF3O2
- Molecular Weight:
- 686.72
- MDL Number:
- MOL File:
- 2253167-09-6.mol
Last updated:2025-04-18 09:51:13
MM-589 Tfa Chemical Properties,Uses,Production
Uses
MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
References
[1] Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839. DOI:10.1021/acs.jmedchem.6b01796
MM-589 Tfa Preparation Products And Raw materials
Raw materials
Preparation Products
MM-589 Tfa Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7408 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5167 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6979 | 58 |
| Guangzhou Jingyan Biotechnology Co., Ltd. | 13822277471 | CHINA | 187 | 58 |
N-[(3R,6S,9S,12R)-6-ethyl-12-methyl-9-{3-[(E)-N''-methylcarbamimidamido]propyl}-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl]-2-methylpropanamide
2253167-09-6
C30H45F3N8O7
