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ChemicalBook >> CAS DataBase List >>Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-

Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-

Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Structure
Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- structure
CAS No.
2649004-88-4
Chemical Name:
Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
Synonyms
KRAS G12C inhibitor 28;Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
CBNumber:
CB611131735
Molecular Formula:
C33H36F2N5O4P
Molecular Weight:
635.64
MDL Number:
MOL File:
2649004-88-4.mol
Last updated:2023-05-21 10:59:17
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Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Properties

Boiling point 826.8±75.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 6.52±0.35(Predicted)

Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Chemical Properties,Uses,Production

Description

KRAS G12C inhibitor 28 is a KRAS G12C inhibitor with an IC50 of 57 nM. KRAS G12C inhibitor 28 has antitumor effects (WO2021113595A1; Example 1)[1].

Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Nantong Hanfang Biotechnology Co. , Ltd. 3674309880 hanfangpharma@126.com China 30968 58
Supplier Advantage
Aladdin Scientific 		58
Nantong Hanfang Biotechnology Co. , Ltd. 58
Pyrido[2,3-d]pyrimidin-2(1H)-one, 1-[4-(dimethylphosphinyl)-2-methyl-6-(1-methylethyl)phenyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- KRAS G12C inhibitor 28 2649004-88-4 C33H36F2N5O4P