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ChemicalBook >> CAS DataBase List >>Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy-

Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy-

Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- Structure
Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- structure
CAS No.
2244129-23-3
Chemical Name:
Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy-
Synonyms
PCSK9-IN-13;(S)-N-(3-((3-Aminopiperidin-1-yl)methyl)-5-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-3-phenoxybenzamide;Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy-
CBNumber:
CB612150067
Molecular Formula:
C30H33N5O2
Molecular Weight:
495.62
MDL Number:
MOL File:
2244129-23-3.mol
Last updated:2025-07-16 16:08:20
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Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- Properties

Boiling point 624.6±55.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
pka 13.26±0.70(Predicted)
form Solid
color Light yellow to yellow

Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- Chemical Properties,Uses,Production

Uses

PCSK9-IN-13(compound 3f) is a potent PCSK9 inhibitor, which can antagonize low-density lipoprotein (LDL) receptor binding by binding to PCSK9, with an IC50 of 537 nM[1].

in vivo

PCSK9-IN-13(compound 3f) (3.28 or 16.4 mg/kg/day, s.c., 14 days) in male C57BL/6 mice dose not show a reduction in total cholesterol at a dose of 3.28 mg/kg, however, a dose of 16.4 mg/kg shows a significant reduction of total cholesterol plasma levels by approximately 10%, and exhibits excellent bioavailability[1].
The pharmacokinetic parameters of PCSK9-IN-13(compound 3f) in C57BL/6 mice

ParameterSCPOIV(single)IV(cassette)
Dose(mg/kg)202050.4
Tmax(h)12--
Cmax(ng/mL)220752.6--
CL(L/h/kg)--1.090.3
Vss(L/kg)--3.879.13
T1/2(h)5.47-9.8625.7
AUC∞(h*ng/mL)16811-46051472
MRT∞(h)--3.5634.9
F(%)91.30.527--

References

[1] Benny J.?Evison, et al. A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.Bioorganic & Medicinal Chemistry

Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 1666 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6708 55
Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3267 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2678 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Beckham Medical Technology Co., Ltd 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Angel Pharmatech, Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58

View Lastest Price from Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PCSK9-IN-13 pictures 2025-07-16 PCSK9-IN-13
2244129-23-3
 US $2180.00-1670.00 / mg 10g TargetMol Chemicals Inc.
  • PCSK9-IN-13 pictures
  • PCSK9-IN-13
    2244129-23-3
  • US $2180.00-1670.00 / mg
  • TargetMol Chemicals Inc.
Benzamide, N-[3-[[(3S)-3-amino-1-piperidinyl]methyl]-5-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-3-phenoxy- PCSK9-IN-13 (S)-N-(3-((3-Aminopiperidin-1-yl)methyl)-5-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-3-phenoxybenzamide 2244129-23-3