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ALK/EGFR-IN-1

ALK/EGFR-IN-1 Structure
ALK/EGFR-IN-1 structure
CAS No.
2730430-08-5
Chemical Name:
ALK/EGFR-IN-1
Synonyms
ALK/EGFR-IN-1;2-Propenamide, N-[5-[[5-chloro-4-[[2-(ethylsulfinyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
CBNumber:
CB614133749
Molecular Formula:
C27H34ClN7O3S
Molecular Weight:
572.12
MDL Number:
MOL File:
2730430-08-5.mol
Last updated:2025-10-28 16:00:23
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ALK/EGFR-IN-1 Properties

Density 1.343±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 12.653±0.70(predicted)

ALK/EGFR-IN-1 Chemical Properties,Uses,Production

Uses

ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].

References

[1] An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653. DOI:10.1016/j.bioorg.2023.106653

ALK/EGFR-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

ALK/EGFR-IN-1 Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from ALK/EGFR-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ALK/EGFR-IN-1 pictures 2025-10-27 ALK/EGFR-IN-1
2730430-08-5
 US $1670.00-2180.00 / mg 10g TargetMol Chemicals Inc.
  • ALK/EGFR-IN-1 pictures
  • ALK/EGFR-IN-1
    2730430-08-5
  • US $1670.00-2180.00 / mg
  • TargetMol Chemicals Inc.
ALK/EGFR-IN-1 2-Propenamide, N-[5-[[5-chloro-4-[[2-(ethylsulfinyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]- 2730430-08-5